Device (1) for filling blood products (12) into at least two administration containers (2), comprising at least one receptacle (3) for dispensing the blood product (12) into the device (1), a channel system (4, 7, 8, 17) connected to carry fluid to the administration containers (2), and an air exhaust assembly (10, 11, 15), where the device (1) further comprises a plate-shaped component (6) in which the channels (7, 8, 17) of the channel system run, through which the administration containers (2) can be filled in parallel with equal volumes of the blood product (12).

A device for transferring fluids in a closed system transfer device using flash for last drop extraction and to reduce coring. The device including a piercing member having a distal end and a proximal end and defining a longitudinal fluid channel. A first opening positioned at the distal end of the piercing member wherein the first opening is in fluid communication with the longitudinal fluid channel. A cover or flash positioned over the first opening. The cover including a pre-cut pattern wherein the cover opens along the pre-cut pattern upon application of a distally directed force from the longitudinal fluid channel. The distal end including the first opening having a steep taper to facilitate last drop extraction.

An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.

A closed system transfer device includes a first adaptor and a second adaptor that attach with one another in a coupled state to form a sealed fluid passage between two reservoirs. The first adaptor can be attached to a first reservoir, and the second adaptor can be attached to a second reservoir. One or both adaptors can include a septum that engages another septum during coupling and decoupling to prevent liquid or vapor from being released to the environment. The device can also include a vent line that equalizes pressure between the two reservoirs. The vent line can include at least one filter to filter gas in device. In addition, or in the alternative, the vent line can be connected in fluid communication with an inflatable membrane that stores gas inside the device and assists in equalizing pressure.

Vented syringes are described herein. A vented syringe includes a syringe body and a plunger body. The syringe body defines a syringe cavity. The plunger body is at least partially disposed within the syringe cavity. The plunger body includes an air intake channel defined within the plunger body. The vented syringe further includes a plunger seal that is sealingly engaged with the syringe cavity to cooperatively define a syringe volume. The vented syringe further includes a one-way valve in fluid communication with the air intake channel and the syringe volume, wherein the one-way valve is configured to prevent fluid flow from the syringe volume to the air intake channel and permit fluid flow from the air intake channel to the syringe volume.

A closed and tamper-evident sealed container, including a fluid transport adapter. The adapter provides for sterile fluid communication between a fluid source outside the container and the container interior when adapter is open. The adapter is adjustable to a closed position wherein the fluid communication ceases. An alternative to the adapter utilizes a sampling attachment that fits into tight engagement with the lid which comprises at least one septum. Coupling the sampling attachment to the lid either causes sharps in the attachment to penetrate the at least one septum or to displace the edges of the septum inward to form a fluid communication with the container interior while the lid remains sealed closed. Other variations include a rotatable sampling attachment, a container with a displaceable bottom wall to act as a syringe and a large volume (e.g., 1500 mL) sealed ampoule which also uses a sampling attachment.

A device for reconstituting a pharmaceutical composition from at least a first component in a first container and a second component in a second container. The device includes a fluidic unit having a first connector coupled to the first container, a second connector coupled to the second container, a pump, and a fluidic circuit connecting the first connector, the second connector and the pump. The first connector includes a crankpin in rotating engagement within a body and including an axial port fluidically couplable to the first container, a radial port fluidically connected to the axial port of the first connector, and at least one channel arranged therein so as to cooperate with the radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin.

An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.

An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.

The present invention provides drug products comprising sealed containers containing a stable liquid recombinant protein, such as an antigen-binding protein, composition and a headspace gas comprising less than 5% oxygen, and methods of producing same. As such, the present invention provides a method for controlling the oxygen levels in the headspace of a drug product in a sealed container comprising a stable liquid recombinant protein composition and a headspace gas comprising less than 21% oxygen.