Topical delivery systems, multi-phase topical application formulations, and methods of use including combining multi-phase ingredients to form a first emulsified system, such as a pre-mixture hydrogel. A second emulsified system is formed to be combined with the pre-mixture hydrogel to form an emulsified topical application formulation. Additives and/or adjuvants are combined with the emulsified multi-phase formulation to form a delivery system. Delivery systems include a combined sustained-release, moisturizing barrier which may be applied to the skin. Multivesicular and/or multi-lamellar characteristics of the barrier provide for time-dependent effects, such as hair follicle softening and/or delayed active ingredient delivery.