In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.

In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.

An oral care composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A mouth rinse composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less.

An oral care composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A mouth rinse composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less.

This invention describes an oral composition, the variations, uses and production method thereof, wherein it is an acidified bioactive complex obtained from association of salts, organic compounds, silicon compounds and phosphates which, when in the mouth, is electrochemically attracted by the tooth, bonding to it and causing ionization of calcium from the dental structures, due to its acidic characteristics. Once bonded to the tooth, the complex gathers dispersed particles in the buccal medium, condensing them and, mainly from calcium, forming a hybrid layer containing silicon-enriched hydroxyapatite. This hybrid layer remineralizes the tooth enamel surface, functioning as a protective shield over the tooth, protecting against the everyday acidic challenges, when the dentin is exposed, this layer obliterates the dentin tubules, relieving the pain caused by dental sensitivity. The layer formation occurs in a self-etching manner, in other words, each application of the oral composition forms a new three-dimensional layer on top of the previous one; Thus, the formation of minerals in acidic medium, exactly in the same medium where mineral loss occurs, enables the formation of the hybrid layer, which enables the product to provide full maintenance of oral health.

This invention describes an oral composition, the variations, uses and production method thereof, wherein it is an acidified bioactive complex obtained from association of salts, organic compounds, silicon compounds and phosphates which, when in the mouth, is electrochemically attracted by the tooth, bonding to it and causing ionization of calcium from the dental structures, due to its acidic characteristics. Once bonded to the tooth, the complex gathers dispersed particles in the buccal medium, condensing them and, mainly from calcium, forming a hybrid layer containing silicon-enriched hydroxyapatite. This hybrid layer remineralizes the tooth enamel surface, functioning as a protective shield over the tooth, protecting against the everyday acidic challenges, when the dentin is exposed, this layer obliterates the dentin tubules, relieving the pain caused by dental sensitivity. The layer formation occurs in a self-etching manner, in other words, each application of the oral composition forms a new three-dimensional layer on top of the previous one; Thus, the formation of minerals in acidic medium, exactly in the same medium where mineral loss occurs, enables the formation of the hybrid layer, which enables the product to provide full maintenance of oral health.

A human oral care composition, includes safe and effective amounts of the fluoride ion and stabilized chlorine dioxide, that may take the form of a paste, gel, rinse, spray, powder, varnish or similar that reduces demineralization and promotes remineralization of teeth. The method includes the topical application of the composition to the human oral cavity (including but not limited to the teeth, gingiva, and tongue), preferably at least once daily, to enhance the anti-caries effect of fluoride by released chlorine dioxide compromising any biofilm present.

A human oral care composition, includes safe and effective amounts of the fluoride ion and stabilized chlorine dioxide, that may take the form of a paste, gel, rinse, spray, powder, varnish or similar that reduces demineralization and promotes remineralization of teeth. The method includes the topical application of the composition to the human oral cavity (including but not limited to the teeth, gingiva, and tongue), preferably at least once daily, to enhance the anti-caries effect of fluoride by released chlorine dioxide compromising any biofilm present.

The invention provides certain compositions and methods for dental care, which alone or in combination with other dental technologies can help to achieve better outcomes in terms of the enhancement of oral hygiene as regards to preservation of the healthy oral and/or dental flora, minimization or a reduction of the proportion of harmful bacteria, and further facilitate the enhancement of a more healthy appearance of teeth and gums. The oral formulation for improving oral and/or dental hygiene, and/or for enhancing the healthy appearance of teeth and gums, comprises Dead Sea salt and at least one synthetic, semi-synthetic or natural cannabinoid, a precursor, a derivative, or any combination thereof, or an extract of a Cannabis plant.

The invention provides certain compositions and methods for dental care, which alone or in combination with other dental technologies can help to achieve better outcomes in terms of the enhancement of oral hygiene as regards to preservation of the healthy oral and/or dental flora, minimization or a reduction of the proportion of harmful bacteria, and further facilitate the enhancement of a more healthy appearance of teeth and gums. The oral formulation for improving oral and/or dental hygiene, and/or for enhancing the healthy appearance of teeth and gums, comprises Dead Sea salt and at least one synthetic, semi-synthetic or natural cannabinoid, a precursor, a derivative, or any combination thereof, or an extract of a Cannabis plant.