Disclosed are high-porosity protein particles useful for carrying one or more agents of interest, methods for their manufacture and use, and products comprising them.

In one aspect, the application relates to novel aqueous oral care compositions useful for combining and delivering potassium salts and a basic amino acid in a high-water composition, for example, to naturally promote nitrate reduction from the oral microbiome, which can result in systemic increases of nitric oxide in blood plasma and can form part of an overall regimen to maintain, reduce, treat or control systemic blood pressure.

In one aspect, the present disclosure relates to oral care compositions comprising a source of zinc, a fluoride source, a zwitterionic surfactant and a taurate surfactant. In one aspect the compositions of the disclosure can be used for the treatment or reduction of erosive tooth demineralization, gingivitis, plaque, and dental caries. In one aspect the oral care composition includes zinc citrate, zinc oxide, arginine, cocamidopropyl betaine and at least one taurate surfactant (e.g., sodium methyl cocoyl taurate).

In one aspect, the present disclosure relates to oral care compositions comprising a source of zinc, a fluoride source, a zwitterionic surfactant and a taurate surfactant. In one aspect the compositions of the disclosure can be used for the treatment or reduction of erosive tooth demineralization, gingivitis, plaque, and dental caries. In one aspect the oral care composition includes zinc citrate, zinc oxide, arginine, cocamidopropyl betaine and at least one taurate surfactant (e.g., sodium methyl cocoyl taurate).

An oral care composition containing a gel phase, an abrasive, and a fluoride source. The gel network phase contains a cold dispersible fatty amphiphile and phase separation is not visually perceptible in the oral care composition.

An oral care composition containing a gel phase, an abrasive, and a fluoride source. The gel network phase contains a cold dispersible fatty amphiphile and phase separation is not visually perceptible in the oral care composition.

The invention includes a toothpaste or other orally applied product to be used at least once daily to help prevent or inhibit the acquisition of a number of infections by oral or pharyngeal tissues, particularly including the “common” cold. These compositions possess a combination of ingredients that is not found in other toothpastes or other orally applied products, and these ingredients work together to synergistically interfere with the acquisition of a number of pathogens. The toothpastes will have the usual dentifrice ingredients known to prevent tooth decay, as well as those that reduce halitosis (i.e., bad breath), and prevent gingivitis. In addition, the toothpastes will include one or more of: 1) GALALCOOL® as an individual compound, and not as an extract component; 2) zinc protoporphyrin IX; and 3) one or more other colorless or low-color tannin(s) each as an individual compound, and not as an extract component.

The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. Accordingly, described herein are methods of inducing or enhancing an adaptive immune response to a cancer in a subject and methods of treating cancer in a subject. In some embodiments, the methods hyperactivate dendritic cells (DCs), which induce T helper type I (TH1) and cytotoxic T lymphocyte (CTL) responses in the absence of TH2 immunity.

The present application is related to cancer immunotherapy, e.g. stimulation of T cell mediated anti-tumor therapy. Accordingly, described herein are methods of inducing or enhancing an adaptive immune response to a cancer in a subject and methods of treating cancer in a subject. In some embodiments, the methods hyperactivate dendritic cells (DCs), which induce T helper type I (TH1) and cytotoxic T lymphocyte (CTL) responses in the absence of TH2 immunity.

Oral care compositions including block copolymer, such as poloxamer. Low water oral care compositions including block copolymer, such as poloxamer, and flavor. Oral care articles including low water oral care composition, the low water oral care composition including flavor and block copolymer, and nonwoven web composition. Low water oral care composition including block copolymer, such as poloxamer, and flavor.