The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and it has been discovered that these compounds are particularly useful in the treatment of certain cosmetic applications and in rejuvenating and beautifying skin and other keratinous tissue of a subject in need. Cosmetic compositions and methods of using said compositions in combination with other components are disclosed herein.

A formulation for providing a disinfecting foam on the basis of an electrochemically activated aqueous saline solution enabling the dispensation as a foam while the microbicidal effectivity the electrochemically activated saline solution is maintained is to be provided. To this end, the formulation comprises at least one surfactant foam carrier component and at least one antimicrobially effective component on the basis of a electrochemically activated aqueous saline solution, the formulation having a content of at least 10 ppm of a free chlorine species selected from the group comprising hydrochlorous acid, hypochlorite ions, sodium hypochlorite or dissolved chlorine gas, and exhibiting a vibration band associated with a CF vibration in the infrared spectrum.

Disclosed are personal care formulations for delivery to the skin of a person in the form of an aerosol comprising: (1) non-propellant components comprising at least one active ingredient in the form of finely divided particles, at least one hydrophobized clay, a hydrophobic carrier comprising trans-1-chloro-3,3,3-trifluoropropene (trans-1233zd) and at least one co-carrier wherein: (i) the weight ratio of said trans-1233zd:co-carrier is from about 0.25:1 to about 4:1; (ii) said trans-1233zd and said co-carrier together comprise at least about 40% by weight of said hydrophobic carrier.

Described herein is dosage of foam including from about 5 cm.sup.3 to about 70 cm.sup.3 of the foam. The foam includes from about 0.5 g to about 4 g of a detersive surfactant; from about 0.001 g to about 4 g propellant; a foam density of from about 0.04 g/cm.sup.3 to about 0.23 g/cm.sup.3; and a bubble size distribution having an R.sub.32 of from about 30 m to about 60 m.

The present disclosure provides a two-component hair care agent including a first component and a second component. The first component and the second component are provided separately from one another. The first component or the second component has a color indicator showing a color change in a pH-value range of from about 3 to about 6, the first component has a pH value in a range of from about 2 to about 4and the second component has a pH value in a range of greater than about 4 to about 9. The present disclosure also provides a method for applying the two-component hair care agent and a method of using the two-component hair care agent.

Described herein is a method of conditioning the hair, the method including providing a hair care composition, adding a hydrofluoropropene to the hair care composition at a concentrated hair care composition to hydrofluoropropene weight ratio of from about 85:15 to about 98:2 to create a pressurized hair care composition, dispensing the pressurized hair care composition from an aerosol dispenser as a foam, applying the foam to the hair, and rinsing the foam from the hair. The hair care composition includes from about 0.5% to about 18% silicone, less than 8% high melting point fatty compound, and less than 5% cationic surfactant. The hair care composition has a viscosity of from about 1 centipoise to about 15,000 centipoise. The hair care composition has a high melting point fatty compound to silicone weight ratio of from about 0 to about 50:50.

The present invention relates to a substantially anhydrous shine enhancing spray composition for keratin fibers, especially for human hair, comprising, in a cosmetically acceptable medium, one or more hair setting film forming polymers and a pyrrolidone carboxylic acid ester.

The current invention concerns a kit suitable for the non-surgical treatment of skin lesions including warts, verrucae, corns, and skin tags said kit comprising a cryogenic body comprising a housing hosting a coolant container and further comprising a cryogenic applicator head, whereby the housing and the cryogenic applicator head extend axially; said cryogenic applicator head is provided with a cryogenic tip for performing a cryogenic treatment to a skin lesion, whereby said coolant container contains a coolant suitable for cooling said tip; the kit further comprises an acid body comprising an acid container containing an acidic composition and having an acid outlet, and an acid dispenser head that axially extends from said acid container, is in fluid communication with said acid outlet, and is suitable for applying a dose of said acidic composition to a skin lesion. The invention also concerns a dosage regimen.

Disclosed are methods of applying a leave-on personal care treatment products comprising: a) providing a container having a nozzle or opening for selectively releasing the contents thereof; b) including in the container a leave-on personal care formulation comprising: (i) an active component for affecting the personal care of the user; (ii) a carrier for the active component, said carrier comprising at least about 50% by weight of trans-HCFO-1233zd and optionally a co-carrier in amounts of up to about 50% by weight; and c) spraying said leave-on personal care formulation from the container and onto the area of the user to be treated.

The present invention is directed to a foaming composition comprising from about 5% to about 13% total surfactant of one or more anionic surfactants; from 0.1% to about 2% of a surfactant soluble antidandruff active; from about 3% to about 15% of a blowing agent, wherein the foaming composition is at a pH of about 3.5 to 6.5