To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C.sub.22H.sub.32Cl.sub.2N.sub.10][C.sub.6H.sub.12NO.sub.3S].sub.2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.

The present specification provides a composition for the prevention or treatment of skin infection which has an excellent treatment effect on skin infection and causes less side effects. A pharmaceutical composition or a cosmetic composition for the prevention or treatment of skin infection of the present invention comprises terbinafine hydrochlodie, chlorhexidine gluconate, and ciclopirox olamine.

The present specification provides a composition for the prevention or treatment of skin infection which has an excellent treatment effect on skin infection and causes less side effects. A pharmaceutical composition or a cosmetic composition for the prevention or treatment of skin infection of the present invention comprises terbinafine hydrochlodie, chlorhexidine gluconate, and ciclopirox olamine.

This antiviral and antibacterial composition includes: at least one of VOSO.sub.4, K.sub.11H [(VO).sub.3(SbW.sub.9O.sub.33).sub.2] and Na.sub.9[SbW.sub.9O.sub.33], and polyhexamethylene biguanide or a salt thereof.

Compositions comprising synergistic blends of organic acids and hydrazones and methods of reducing bacterial and fungal contamination using the blends are disclosed.

According to the present invention there is provided a cosmetic composition comprising a cosmetically acceptable carrier and a preservative system, wherein the preservative system comprises: (i) an antimicrobial agent; (ii) a chelating agent comprising ethylenediamine tetraacetic acid (EDTA) or a derivative thereof; and (iii) an antimicrobial booster agent selected from the group consisting of ethylhexylglycerin, caprylyl glycol, hydroxy acetophenone, caprylhydroxamic acid, phenethyl alcohol, p-anisic acid, glyceryl caprylate, levulinic acid, sodium levulinate, propanediol, hexanediol, pentylene glycol, capryloyl glycine, methylpropanediol, phenylpropanol, sodium anisate, and combinations thereof, wherein the antimicrobial agent is present in an amount of from about 0.001% to about 1% by weight of the composition.

According to the present invention there is provided a cosmetic composition comprising a cosmetically acceptable carrier and a preservative system, wherein the preservative system comprises: (i) an antimicrobial agent; (ii) a chelating agent comprising ethylenediamine tetraacetic acid (EDTA) or a derivative thereof; and (iii) an antimicrobial booster agent selected from the group consisting of ethylhexylglycerin, caprylyl glycol, hydroxy acetophenone, caprylhydroxamic acid, phenethyl alcohol, p-anisic acid, glyceryl caprylate, levulinic acid, sodium levulinate, propanediol, hexanediol, pentylene glycol, capryloyl glycine, methylpropanediol, phenylpropanol, sodium anisate, and combinations thereof, wherein the antimicrobial agent is present in an amount of from about 0.001% to about 1% by weight of the composition.

The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.