In order to provide a new agent for actively controlling hair growth in subjects, the present disclosure is directed to an active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein the active agent activates, enhances, inactivates, blocks or dampens the cellular response of the transient receptor potential ion channel TRPM5 or interferes with the expression of the ion channel. Furthermore, the present disclosure is directed to compositions for use as a cosmetic or medicament in the treatment of hair growth; the composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.

The disclosure relates to methods for coloring keratinous substrates using solubilized vat dyes, as well as compositions and kits suitable for carrying out the methods. The disclosure also relates to novel solubilized vat dyes.

A liquid compositions comprising at least one non-natural cooling compound and lactic acid, and the use of said composition in a flavour or fragrance composition.

Compositions comprising at least one cooling compound and a solvent, and the use of said composition in a flavour or fragrance composition.

Among the various aspects of the present disclosure is the provision of compositions and methods for treating hair regeneration disorders or conditions such as hair loss or thinning. An aspect of the present disclosure provides for a method of treating hair loss, promoting hair growth, or treating hair loss, such as alopecia or telogen effluvium, comprising administering a TRPV4 activating agent to a subject.

A dye composition I, comprises: a) at least one oxidative dye(s), b) at least one thickener selected from anionic polymer(s), and c) at least one antioxidant including thiol-derived reducer(s). A kit comprises (1) the dye composition I and (2) oxidizing composition IL, comprising at least one oxidant.

The present invention relates to a process for treating keratin materials, especially human keratin fibers, comprising the application of a composition comprising i) at least one flavin derivative and ii) at least one polymerizable molecule, preferably a photopolymerizable molecule, and at least one step of exposing said materials to artificial or natural light radiation, in particular for caring for and/or repairing the keratin materials.

Disclosed is a topical skin composition. The composition can include water, caprylic/capric triglyceride, Butyrospermum parkii (shea) butter, Helianthus annuus (sunflower) seed oil, cetyl alcohol, glyceryl stearate, and beeswax.

Provided is a method for inhibiting the growth of Gram-positive bacteria, including contacting said bacteria with a first compound and a second compound, wherein the first compound is a compound of Formula I: ##STR00001##
and the second compound is an antibiotic other than a compound of Formula I. Also provided is a composition including the first compound and the second compound.

The invention relates to a combination comprising a carotenoid, a carotenoid metabolite, a carotenoid derivative, analogue or an ester or salt thereof and a second component selected from the group consisting of an inhibitor of one or more members of the BCL-2 anti-apoptotic protein family, an activator of pro-apoptotic BCL-2 family members, a senolytic agent and a senomorphic agent. The invention also relates to a food, a cosmeceutical, a nutraceutical, a cosmetic or pharmaceutical composition comprising the combination of the invention and its use in a cosmetic method and it medical uses.