The present invention provides a formulation for increasing the efficiency and safety of cutting a tooth structure during dental procedures. In accordance with one form of the present invention, there is provided a formulation including 10 to 30% by weight of ethanol; 5 to 15% by weight of glycerol; 10 to 20% by weight of xylitol; 0.5 to 5% by weight of a nonionic surfactant and emulsifying agent; 0.15 to 0.5% by weight of a plurality of flavoring agents; and 51 to 77.5% by weight of water.

A cosmetic or dermatological compositions of oil-in-water emulsion type, including, in a physiologically acceptable medium, at least gemini surfactant of formula (I): ##STR00001##
in which R.sub.1 and R.sub.3 denote, independently of one another, an alkyl radical containing from 1 to 25 carbon atoms; R.sub.2 denotes a spacer consisting of a linear or branched alkylene chain containing from 1 to 12 carbon atoms; X and Y denote, independently of one another, a group —(C.sub.2H.sub.4O).sub.a—(C.sub.3H.sub.6O).sub.bZ; n ranges from 1 to 10, in combination with an effective amount of at least one semi-crystalline polymer which is solid at ambient temperature and which has a melting point below 70° C., said polymer having a number-average molecular mass greater than or equal to 2000, said emulsion having a proportion of fatty phase of greater than 10% by weight relative to the total weight of the composition and including more than 40% by weight of non-volatile oil(s) relative to the weight of the fatty phase.

An oil-in-water cosmetic composed of an aqueous phase and an oil phase and comprising hydrophobized inorganic powder, a fatty acid soap, a nonionic surfactant and a hydrophilic polymer, including an oil that contains a non-silicone oil and including hydrophobized iron oxide powder and hydrophobized pigment-grade titanium oxide powder in the oil phase and the aqueous phase, wherein the contents of the hydrophobized pigment-grade titanium oxide powder in the oil phase and in the aqueous phase are, respectively, greater than 0.5 mass % and less than 5 mass %, and greater than 2.5 mass % and less than 20 mass %, the nonionic surfactant has an overall HLB value of 6 to 15, an aminoalkylsulfonic acid polymer is contained as a hydrophilic polymer, and the total non-silicone oil content is greater than 5 mass % and less than 30 mass %.

Described are effervescent dissolvable solid structures having fibers formed from a composition comprising surfactant and water soluble polymeric structurant, having a total dissolvable solid structure density of from about 0.100 g/cm.sup.3 to about 0.380 g/cm.sup.3, having a surfactant dose of from about 0.5 to about 2.0 g, and a surfactant density of from about 0.1 g/cm.sup.3 to about 0.3 g/cm.sup.3. Also described are processes for manufacturing the Dissolvable Solid Structure.

A multi-phase oral composition with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier, which is rinseable from a surface and/or has a high water dispersibility. A jammed oil-in-water composition with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier, which is rinseable from a surface and/or has a high water dispersibility. Methods of using disclosed compositions for active agent delivery.

Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜37° C. as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without lyophilization process.

Disclosed are stable, non-irritating, retinoid containing formulations for topical application to the skin for modulated sheet-peeling of the skin without inflammatory response that retards healing of the skin. The topical formulations have concentration levels of ingredients, including retinol, a retinol activation system having a surfactant and a solvent, anti-inflammatory agents, that are formulated for exfoliating skin in skincare treatments such as chemexfoliation, peeling, dermal restructuring, without associated inflammatory affects, such as irritation, redness, drying, oozing, swelling, tenderness of skin, which retard healing of the skin. Also provided are methods for the formulation, manufacture and use of the disclosed formulations.

Tablets are prepared with friability reducing agents to yield tablets that are more resistant to breakage or crumbling, but with satisfactory hardness. The friability reducing agents include low molecular weight polyethylene glycol as well as similar agents exhibiting at least three percent (3%) hydroxide moieties and a water solubility of at least eighty percent (80%) (w/w %) in room temperature water. The tablets may comprise an active agent and excipient of almost any type, and about 0.1-about 0.5% by weight friability reducing agent. They exhibit a hardness of at least eighty percent (80%) of the same tablet prepared without the friability reducing agent.

Personal care compositions in the form of a stable oil-in-water emulsion comprises: (i) a continuous aqueous phase N comprising water; (ii) a discontinuous phase comprising foam forming component (s), tans-1-chloro-3, 3, 3-trifluoropropene (1233zd (E)) and trans-1-3, 3, 3-tetrafluoropropene (1234ze (E)), wherein said 1233zd (E) and said 1234ze (E) together comprise from about 40% to about 60% by weight of said personal car composition and are present in a trans1233zd:trans1234ze weight ratio of from about 8:1 to about 8:1; (iii) an emulsifier having an HLB value of from about 7 to about 18 and which may be present in the continuous and/or discontinuous phase; and (iv) one or more active ingredients which maybe present in the continuous and/or discontinuous phase. A method of treating human skin, hair and/or mucous membranes comprises providing the personal care composition.

The oil-in-water type emulsified cosmetic includes: (A) a powder, (B) a water-soluble thickener, and (C) a surfactant, wherein the content of the component (A) is 1% to 30% by mass based on the total amount of the cosmetic, the component (A) contains (A1) an N-acyl acidic amino acid-treated powder, the component (C) contains (C1) a solid nonionic surfactant having a hydrophile-lipophile balance (HLB) value of less than 7 and (C2) a surfactant having an HLB value of 7 or greater, and the mass ratio [(C1):(C2)] between the component (C1) and the component (C2) is 1.5:1 to 30:1.