The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.

Disclosed are a sheet-type mask gel composition, mask sheet including the same and a method of manufacturing the mask sheet. The sheet-type mask gel composition includes an emulsion composition, a polyol, and a thickener, wherein the emulsion composition includes at least one selected from butters, oils, waxes, and a combination thereof, a surfactant and a polyol.

A nonaqueous composition for external use on the skin including a strongly hydrophilic amphiphilic solid active ingredient-surfactant complex dissolved or dispersed as a particle having a particle size of 2 nm to 200 nm in an oil phase. A strongly hydrophilic amphiphilic solid active ingredient-surfactant complex dissolved or dispersed as a particle having a particle size of 2 nm to 200 nm in the oil phase can be prepared by: adding a strongly hydrophilic amphiphilic solid active ingredient to a water phase to obtain a water phase mixture; adding a surfactant to an oil phase to obtain an oil phase mixture; mixing the obtained water phase mixture with the oil phase mixture to obtain a water-in-oil emulsion; freeze-drying the water-in-oil emulsion to obtain a strongly hydrophilic amphiphilic solid active ingredient-surfactant complex; and dissolving or dispersing the obtained strongly hydrophilic amphiphilic solid active ingredient-surfactant complex in an oil.

Disclosed are certified natural skin compositions and related methods of use. Certified natural compositions include diaper rash compositions, antioxidant sunscreen compositions, with or without natural sparkle or shimmer ingredient(s), and after-sun, tan-enhancing bronzer, skin toner or moisturizer composition with natural sparkle or shimmer. The inventive natural skin compositions are specifically formulated with natural ingredients, such that the products are suitable for certification as “natural” and/or “organic” products, and more particularly formulated with a variety of high-quality ingredients that care for and protect skin.

A composition includes polyphenolic particles and a surfactant, on the polyphenolic particles. The composition is lipophilic. The polyphenolic particles are non-pigmentary. A dispersion includes the polyphenolic particles, the surfactant, and a carrier vehicle. The carrier vehicle may be a cosmetically-acceptable fluid or a wax that is lipophilic.

A novel lysophospholipid concentrate produced by a process comprising the steps of combining (i) a de-oiled lecithin and (ii) from about 0.5 to about 2% of an enzyme with PLA2 activity. The lysophospholipid concentrate is a pourable, homogenous mixture/solution at or about room temperature with has no significant visible precipitate that (a) has an HLB of greater than 12, (b) contains greater than about 20% lysophosphatidylcholine, and (c) contains greater than about 10% lysophosphatidic acid or an LPA-mimetic. Novel low-urea retinoate compounds produced by the reaction of (a) retinoic acid and (b) one or both of glycerine and/or a monoacylglyceride in the presence of a carbodiimide coupling agent, and preferably in the presence of p-toluene sulfonic acid. The low-urea retinoate is a pourable, homogenous mixture/solution at or about room temperature with no significant visible precipitate.

Methods and compositions for rapid and efficient assembly of substrates (e.g., fibers) coated with lamellar vesicles are provided, wherein the vesicles are more strongly attached to the substrate than those made using other methods.

Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.

The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.