The present disclosure provides nucleic acid carriers comprising one or more layers comprising multiple monomers, wherein each monomer comprises: a first and a second oligonucleotide; wherein a central portion of each of the first and second oligonucleotides is complementary to each other, forming a double-stranded region, wherein the two terminal portions of the first oligonucleotide are not complementary to the two terminal portions of the second oligonucleotide, forming four terminal arms; and at least one targeting agent conjugated to at least one peripheral terminal arm, wherein when the at least one targeting agent is an miRNA. The present disclosure also provides pharmaceutical composition comprising any of the nucleic acid carriers described herein, and a pharmaceutically acceptable vehicle. The present disclosure also provides methods of inducing an immune response in an animal comprising administering to the animal any of the nucleic acid carriers described herein.

The invention relates to an aqueous extract enriched with small RNA having a maximum length of 150 nucleotides, from plant material. The invention relates to an aqueous extract of plant material, enriched with small RNAs having a maximum length of 150 nucleotides, which can be obtained by such a method, as well as to the compositions comprising such an extract and to their cosmetic uses for combating the signs of skin aging and for improving the hydration of the skin.

A composition for external use is provided, comprising a phosphate ester of uridine or a physiologically acceptable salt thereof as an active ingredient for moisturizing, anti-wrinkling, anti-sagging, wound healing, prevention of hair loss, hair growth, or prevention/treatment of atopic dermatitis.

Disclosed are methods improving or stimulating hair regeneration; treating, inhibiting, or reducing hair loss; improving or stimulating hair growth; treating, inhibiting, or reducing pigmentation loss; and/or improving or stimulating pigmentation production in a subject with one or more autophagy inducing agents.

The present invention provides an externally applied composition capable of enhancing a stimulatory effect of an essential oil on IGF-1 secretion, the composition including (A) essential oil; and (B) at least one member selected from the group consisting of purine substances and salts thereof. Further, the present invention provides an externally applied composition capable of increasing the stratum corneum water content of the skin and maintaining transepidermal water loss at an appropriate level.

Various aspects of the invention relate to compositions and methods for preventing and treating skin conditions, such as acne. Also provided herein are methods of determining whether a subject is at risk for a skin condition.

Described are emulsions and emulsion systems comprising intrinsically-disordered proteins (e.g. MEG proteins) as stabilizers for protein rich compositions.

The present invention provides a sunscreen composition comprising two or more oil-soluble ultraviolet absorbers and composite silicone particles having an average particle diameter of 10 m or less.

The invention relates to a botulinum neurotoxin-encoding nucleic acid for therapeutic use. The invention further relates to the transfection of skeletal muscle cells and smooth muscle cells and the glands of the skin, and of other skin cells with botulinum neurotoxin (BoNT)-encoding nucleic acids (RNA or DNA) with or without the use of a secretory signal, for therapeutic and/or cosmetic purposes.

The present invention relates to a pharmaceutical composition or a cosmetic composition for preventing or treating hair loss, or promoting hair growth. The composition according to the present invention exhibits an excellent effect of preventing or treating hair loss and promoting hair growth, and can be safely used regardless of sex and age.