Skin care compositions are provided which contain thermus thermophiles ferment and silybin and provide anti-aging and reparative effect for skin. The compositions may also include one or more additional substances selected from carnosine, adenosine and CG-EDP3. The substances are dispersed in an aqueous carrier, such as water, to be applied to the skin in a spreadable form.

Provided are peptide nucleic acid derivatives targeting a 3′ splice site of the human SNAP25 pre-mRNA. The peptide nucleic acid derivatives potently induce at least a splice variant of the human SNAP25 mRNA in cells, and are useful to safely treat dermatological indications or conditions involving the expression of the human SNAP25 protein by topical administration.

The present invention provides an agent for activating proliferation of follicle dermal papilla cells comprising an acidic saccharide alkaline earth metal salt, wherein the acidic saccharide is selected from the group consisting of a phosphorylated saccharide and lactobionic acid. The acidic saccharide is preferably a phosphorylated saccharide. The alkaline earth metal salt is preferably a calcium salt or a magnesium salt. In accordance with the present invention, the proliferation of follicle dermal papilla cells is promoted. Thus, the agent for activating proliferation of follicle dermal papilla cells is expected to produce hair-restoration and hair-growth effects such as treatment of hair thinning, prevention of hair loss, promotion of hair restoration, and promotion of hair growth.

Provided are a multilayered cationic liposome for enhancing skin absorption, a cosmetic composition including the same, and a method of preparing the same.

6-aryl-9-glycosidpurines of general formula I

##STR00001##

and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents β-D-arabinofuranosyl or β-D-2′-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro.

The present disclosure provides a method for preparing an anti-wrinkle functional cosmetic substance comprising cutting herbal materials comprising angelica gigas root, rehmannia glutinosa root, a paeonia albiflora root, mentha arvensis, angelica dahurica root, scrophularia buergeriana, rheum undulatum root/stalk/stem, sanguisorba officinalis root, and cinnamomum cassia bark into pieces, putting a mixture of the herbal material pieces, talc, a pearl powder, deep ocean water into an extractor, sterilizing the mixture, then fermenting the mixture by mixed lactobacillales strain, and then hot-water extracting the mixture into a solid, freeze-drying the extracted solid into a freeze-dried powder, and dissolving and high-speed mixing the freeze-dried powder, adenosine, and borax in a beeswax, a perilla oil, an olea europaea (olive) fruit oil, and a helianthus annuus (sunflower) seed oil heated and chamaecyparis obtusa water heated.

The present invention relates to a long-lasting powder essence composition with improved coloring and skin feeling and its preparation method. The powder essence composition is a high-fitting coloring powder not likely to smear or wear off. The composition turns into liquid the moment it is rubbed on the skin to offer a natural color tone like water color, keeps the color clear without getting cakey even when it is reapplied multiple times, and delivers a clearer color as it glides on the skin to break powder and water particles. The powder essence composition according to the present invention is also a powder emulsion, which makes the skin feel light and hydrated rather than sticky or stuffy when applied to the skin and stays long due to its water-resistant function. In addition, the powder essence composition according to the present invention contains different functional moisturizing agents to provide plenty of nourishment when applied to the skin. The composition makes the skin feel fresh and hydrated rather than stuffy or heavy, lightly sinks into the skin like nothing is applied on the skin, to display a strong tint function, stays long just with one touch and has a good water-resistant effect, so it does not bleed when in contact with water.

A dermatological and/or topical composition, which contains retinaldehyde, and DNA.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.