The present invention provides a delivery system for the treatment and/or prevention of infectious pathological changes, including compositions comprising polyhexanide, various pharmaceutical formulations, and processes for using these formulations in oral treatment modalities.

The present invention relates to a stable protease formulation. Furthermore, it relates to a stable protease formulation for use in medicine and cosmetics, as well as a method of preventing and reducing biofilm formulation.

The present invention relates to a stable protease formulation. Furthermore, it relates to a stable protease formulation for use in medicine and cosmetics, as well as a method of preventing and reducing biofilm formulation.

Transglutaminase variants are disclosed. Applications of use for the variants, including use as preservatives, biocidal agents, and for modification of proteins, are disclosed.

Transglutaminase variants are disclosed. Applications of use for the variants, including use as preservatives, biocidal agents, and for modification of proteins, are disclosed.

The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.

The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.

Compositions and methods to treat biofilms are disclosed based on the discovery of the role of the disaccharide trehalose in microbial biofilm development. In various embodiments to treat body-borne biofilms systemically and locally, the method includes administering trehalase, the enzyme which degrades trehalose, in combination with other saccharidases for an exposition time sufficient to adequately degrade the biofilm gel matrix at the site of the biofilm. The method also includes administering a combination of other enzymes such as proteolytic, fibrinolytic, and lipolytic enzymes to break down proteins and lipids present in the biofilm, and administering antimicrobials for the specific type(s) of infectious pathogen(s) underlying the biofilm. Additionally, methods are disclosed to address degradation of biofilms on medical device surfaces and biofilms present in industrial settings.

One or more techniques and/or systems are disclosed for a composition or formulation that can be used as a surface applied treatment for reducing odors, enhancing a user experience with pleasant scents, and mitigating skin irritation for items worn close to a user's skin. The composition can comprise a natural astringent, such as witch hazel. Further, the composition can comprise an essential oil, such as lavender, mint, tea tree, grapefruit, ylang ylang, eucalyptus, and vanilla, along with distilled water. These ingredient can be readily mixed together, and packaged in an appropriate container, such as a spray bottle. The composition can be applied to a target surface, such as the inside of a mask, by spraying applying the composition.

One or more techniques and/or systems are disclosed for a composition or formulation that can be used as a surface applied treatment for reducing odors, enhancing a user experience with pleasant scents, and mitigating skin irritation for items worn close to a user's skin. The composition can comprise a natural astringent, such as witch hazel. Further, the composition can comprise an essential oil, such as lavender, mint, tea tree, grapefruit, ylang ylang, eucalyptus, and vanilla, along with distilled water. These ingredient can be readily mixed together, and packaged in an appropriate container, such as a spray bottle. The composition can be applied to a target surface, such as the inside of a mask, by spraying applying the composition.