Methods, compositions, and devices for enhancing transdermal delivery and/or bioavailability of large agents.

The present invention is directed to a depilatory composition which comprises a depilatory active and at least one material which alters the thermal properties of the composition by either having a higher heat of fusion or a lower thermal conductivity than the bulk.

A stomatological composition is provided. The stomatological composition is capable of stably compounding an antibody obtained from a hen egg yolk, and preventing diseases in an oral cavity such as odontonecrosis and periodontal disease from occurring, or improving such diseases in the oral cavity. The stomatological composition includes at least one selected from the group consisting of lipase, protease and the antibody obtained from the hen egg yolk, citric acid and a metal salt of citric acid. A total amount of the lipase, the protease and the antibody obtained from the hen egg yolk is in the range of 0.001 to 10 wt %. When an amount of the citric acid is defined as “A” [wt %] and an amount of the metal salt of citric acid is defined as “B” [wt %], the following relation is satisfied: 0.005≦A/B≦1. Further, the stomatological composition of the present invention includes a polyglyceryl fatty acid ester or an amino acid-based ampholytic surfactant as a surfactant. Further, the stomatological composition of the present invention includes a collagen.

A stomatological composition is provided. The stomatological composition is capable of stably compounding an antibody obtained from a hen egg yolk, and preventing diseases in an oral cavity such as odontonecrosis and periodontal disease from occurring, or improving such diseases in the oral cavity. The stomatological composition includes at least one selected from the group consisting of lipase, protease and the antibody obtained from the hen egg yolk, citric acid and a metal salt of citric acid. A total amount of the lipase, the protease and the antibody obtained from the hen egg yolk is in the range of 0.001 to 10 wt %. When an amount of the citric acid is defined as “A” [wt %] and an amount of the metal salt of citric acid is defined as “B” [wt %], the following relation is satisfied: 0.005≦A/B≦1. Further, the stomatological composition of the present invention includes a polyglyceryl fatty acid ester or an amino acid-based ampholytic surfactant as a surfactant. Further, the stomatological composition of the present invention includes a collagen.

A composition of matter for dental plaque removal comprising at least one of a strain of the bacteria Bacillus licheniformis and the extracellular enzymes produced by B. licheniformis, and at least one of a natural and synthetic polymer, are disclosed. A method of manufacturing an animal chew or food item coated with the disclosed composition of matter, and animal chews or food items produced therefrom, are also disclosed.

A composition of matter for dental plaque removal comprising at least one of a strain of the bacteria Bacillus licheniformis and the extracellular enzymes produced by B. licheniformis, and at least one of a natural and synthetic polymer, are disclosed. A method of manufacturing an animal chew or food item coated with the disclosed composition of matter, and animal chews or food items produced therefrom, are also disclosed.

Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.

Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.

A method for increasing cellular viability in cells of keratin surfaces after exposure to UV light and/or detoxifying cells of debris that impedes healthy metabolic function by topically applying to the keratin surface a composition containing at least one autophagy activator and at least one DNA repair enzyme and a method for making a topical composition comprising the steps of (a) identifying an ingredient that activates cellular autophagy in keratinocyte cultures in vitro, and (b) formulating the ingredient into a topical composition in combination with at least one DNA repair enzyme.

A method for increasing cellular viability in cells of keratin surfaces after exposure to UV light and/or detoxifying cells of debris that impedes healthy metabolic function by topically applying to the keratin surface a composition containing at least one autophagy activator and at least one DNA repair enzyme and a method for making a topical composition comprising the steps of (a) identifying an ingredient that activates cellular autophagy in keratinocyte cultures in vitro, and (b) formulating the ingredient into a topical composition in combination with at least one DNA repair enzyme.