This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

The disclosure relates to the field of reducing malodor that is due to bacterial conversion of molecules that are present in sweat. This disclosure describes purified enzymes, lyophilized or non-living bacteria, bacterial lysates, and/or bacterial fragments that contain the functional potential to fully catabolize the human skin lipids and squalene, so no malodor arises. The disclosure also describes enzymes that produce a natural fragrance from squalene breakdown products. The compounds of the disclosure can, thus, be used in deodorants, washing powders, clothing finishing agents or in any method to reduce malodor.

The disclosure relates to the field of reducing malodor that is due to bacterial conversion of molecules that are present in sweat. This disclosure describes purified enzymes, lyophilized or non-living bacteria, bacterial lysates, and/or bacterial fragments that contain the functional potential to fully catabolize the human skin lipids and squalene, so no malodor arises. The disclosure also describes enzymes that produce a natural fragrance from squalene breakdown products. The compounds of the disclosure can, thus, be used in deodorants, washing powders, clothing finishing agents or in any method to reduce malodor.

The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier.

A topical skin treatment for the mitigation of various skin irritations and abnormal skin conditions, the composition and method for making the topical skin treatment providing a mixture of tea extracts from the snow mushroom, Reishi mushrooms, and other various organic ingredients in a range of constituent amounts to form a homogeneous liquid compound solution applied to the skin in liquid or aerosol form.

A topical skin treatment for the mitigation of various skin irritations and abnormal skin conditions, the composition and method for making the topical skin treatment providing a mixture of tea extracts from the snow mushroom, Reishi mushrooms, and other various organic ingredients in a range of constituent amounts to form a homogeneous liquid compound solution applied to the skin in liquid or aerosol form.

The invention relates to compositions and methods for treating an acne. In one embodiment, the invention relates to the use of an RNA inhibitor to treat an acne.

The invention relates to compositions and methods for treating an acne. In one embodiment, the invention relates to the use of an RNA inhibitor to treat an acne.