In a method for manufacturing black ginseng low molecular collagen essence, koji mould is added to ginseng, to manufacture black ginseng. The black ginseng is mixed with oligosaccharide, to manufacture black ginseng concentrate. The black ginseng concentrate is fermented and sterilized after adding collagen to the black ginseng concentrate.

In a method for manufacturing black ginseng low molecular collagen essence, koji mould is added to ginseng, to manufacture black ginseng. The black ginseng is mixed with oligosaccharide, to manufacture black ginseng concentrate. The black ginseng concentrate is fermented and sterilized after adding collagen to the black ginseng concentrate.

A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

Topical applicators containing mycological biopolymers are suitable for applying health or cosmetic products to the skin or lips of a subject. The applicators are made from biodegradable mycological biopolymers that are grown from fungi in the presence of a growth medium under a predetermined environment of relative humidity, temperature, carbon dioxide, oxygen and air flow. The topical applicators containing the mycological biopolymers may further contain beneficial agents or products that that may be transferred to the skin or lips, thereby enhancing the health or beauty of a subject.

Topical applicators containing mycological biopolymers are suitable for applying health or cosmetic products to the skin or lips of a subject. The applicators are made from biodegradable mycological biopolymers that are grown from fungi in the presence of a growth medium under a predetermined environment of relative humidity, temperature, carbon dioxide, oxygen and air flow. The topical applicators containing the mycological biopolymers may further contain beneficial agents or products that that may be transferred to the skin or lips, thereby enhancing the health or beauty of a subject.

Described herein are carbo-ionic cultures and extracts and applications thereof. The carbo-ionic cultures are grown in media containing an organic component and an inorganic component and the proportions and compositions of these components can be tailored to produce carbo-ionic extracts with specific properties such as, for example, the ability to provide power to a light emitting diode (LED) with a specific voltage. The carbo-ionic cultures and extracts have further uses including enhancing the growth of plants, including plants grown from tissue culture, and as supplemental nutrients for cultures of industrially, commercially, and/or scientifically-important microorganisms. Also described herein are microbial electric circuits comprising the carbo-ionic cultures and extracts described herein as well as applications of those circuits.

An object of the present invention is to prepare a novel food-derived exosome composition and to provide a cancer inhibitor or an agent for preventing decrease in tissue elasticity or an agent for improving elasticity containing a novel active ingredient. As a result of intensive studies on the purification process, the inventors have found that an exosome can be extracted from yeast mash and moromi by a unique production method. The inventors have found that the exosome recovered from the yeast mash and the moromi has a cancer cell proliferation inhibition ability, an ability to promote increase in the amount of granzyme, and an ability to promote expression of collagen and elastin. Accordingly, the inventors provide a composition for treating or preventing cancer and an agent for preventing decrease in tissue elasticity or an agent for improving elasticity, containing exosomes derived from yeast mash and moromi of sake.

An object of the present invention is to prepare a novel food-derived exosome composition and to provide a cancer inhibitor or an agent for preventing decrease in tissue elasticity or an agent for improving elasticity containing a novel active ingredient. As a result of intensive studies on the purification process, the inventors have found that an exosome can be extracted from yeast mash and moromi by a unique production method. The inventors have found that the exosome recovered from the yeast mash and the moromi has a cancer cell proliferation inhibition ability, an ability to promote increase in the amount of granzyme, and an ability to promote expression of collagen and elastin. Accordingly, the inventors provide a composition for treating or preventing cancer and an agent for preventing decrease in tissue elasticity or an agent for improving elasticity, containing exosomes derived from yeast mash and moromi of sake.

The present disclosure relates to a topical skin care composition comprising colloidal oatmeal in combination with a Vincetoxicum officinale extract and/or a Populas alba extract. The present disclosure further relates to methods of treating symptoms of itch, redness, flaking, dryness, and/or roughness of the skin, scalp, and/or mucous membrane using such topical skin care compositions.