The present disclosure provides compositions and methods relating to the use of exosomes derived from human dermal papilla (DP) cells. In particular, the present disclosure provides novel compositions and methods for generating and maintaining exosomes derived from DP spheroids, as well as compositions and methods for delivering exosomes to a subject for various therapeutic purposes, such as the treatment of diseases and conditions related to hair follicle development.

Disclosed herein are hair care compositions and methods of using same. The compositions may be substantially anhydrous, and optically clear. The hair care compositions, when mixed with water, create an exothermic reaction, for example, when mixed with hair that has been pre-wetted. The mixture with water further causes the composition to become opaque, much like a traditional conditioning agent. The compositions may be left on the wetted hair and subjected to heat for enhanced treatment of the hair.

We describe the use of an exosome for the preparation of a pharmaceutical composition to promote or enhance would healing or hair growth, or both, in an individual. The exosome may be derived from a stem cell such as a mesenchymal stem cell (MSC).

The present invention relates to a gingival fibroblast-derived product for use in the treatment or prevention of an immune-related disease in an individual.

An agent of the present invention comprising poultry feet or a processed product thereof, preferably a hydrolysate of an extract of poultry feet, promotes hyaluronic acid production, thereby exhibiting excellent effects of preventing or treating a joint disorder, improving skin dryness, wrinkles or skin tension, moisturizing the skin, etc. The agent is thus useful as a medicament, a quasi-drug, a cosmetic product, a food product or an animal feed.

A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.

This invention provides a method of causing proliferation of stem cells and their derivative cells and thus solves the cosmetic problems of wrinkles and sagging. Mechanical stress is applied to skin that includes sebaceous glands, thereby causing proliferation of stem cells and their derivative cells.

Compositions and methods for reducing the symptoms of skin conditions associated with the nail and surrounding tissue are provided. A medicated pad for cleaning and treating the nail and surrounding tissue is described, wherein said pad is saturated with a therapeutic composition comprising certain botanicals, an antimicrobial agent, a surfactant, and a moisturizing agent. The skin and nail conditions can include fungal infections of the nails. Kits for treating fungal infections of the nails are likewise described. Optionally, the kit may include a hydrating composition which includes shea butter, aloe, vitamins, arnica, emu oil, urea, and Vitamins C, A, E, and D. A bandage comprising a therapeutic pad instilled with an antifungal agent is also provided.

Compositions for the cosmetic and/or therapeutic treatment of skin are provided. Methods for preparing the compositions and methods for using the compositions for the treatment of skin are also provided.

Cosmetic formulations and compositions customized and/or personalized for rejuvenation of skin and/or hair are described. The cosmetic formulations are customized and/or personalized to include an extract and/or one or more molecular components in amounts and ratios naturally produced by rejuvenated cells or by cells modified toward rejuvenation. These cells are of skin and/or hair origin that have been reprogrammed, in which the skin and/or hair cells, having been rejuvenated and/or modified from the original cell, are initially obtained from a subject for which a customized cosmetic composition is for, or from a subject representative of a person for which a customized cosmetic composition is for. Reprogramming of the skin and/or hair cells provide rejuvenated cells, embryonic stem cell-like pluripotent cells, and/or transdifferentiated or differentiated young or younger cells that have been transdifferentiated from the rejuvenated or modified cells or differentiated from the embryonic stem cell-like pluripotent cells. Methods of selecting, preparing, and formulating the customized cosmetic products are also described.