The invention relates to a nicotine chewing gum giving an immediate release and uptake of nicotine as well as an extended release and uptake of nicotine as well as describing suitable manufacturing processes for such chewing gum formulations and the use of the chewing gum for the treatment of a human being suffering from cravings from tobacco and/or e-cigarette dependency.

This application provides a composition and a product thereof. The composition includes arecoline and an acid. The composition is convenient to use and widely used, with a low pH value and weak irritation.

At least one example embodiment relates to an oral product. In at least one example embodiment, the oral product comprises a liquid mixture. The liquid mixture includes a triglyceride and liquid nicotine dissolved in the triglyceride. At least a portion of the liquid nicotine is free-base nicotine. A weight ratio of the triglyceride to the liquid nicotine in the liquid mixture ranges from 1:1 to 9:1. At least one example embodiment relates to a method of increasing buccal absorption of nicotine in an oral product.

An apparatus for forming a nicotine gum may include a first pair of drums configured to receive and press a nicotine gum mixture to a first thickness so as to form a first pressed sheet and a second pair of drums configured to receive and score the first pressed sheet so as to form a scored sheet including a plurality of gum pieces. The second pair of drums may include a first drum having a first die with a first pattern and a second drum having a second die with a second pattern. The second pattern may be a mirror image of the first pattern. The first drum and the second drum may be spaced such that as the first pressed sheet passes between the first drum and the second drum, the first die and the second die at least score the first pressed sheet.

At least one example embodiment relates to a chewing gum. In at least one example embodiment, the chewing gum comprises a gum base polymer and oil. The gum base polymer includes polyvinyl acetate (PVA) in an amount ranging from 35 weight percent to 55 weight percent of the chewing gum. The oil is present in an amount greater than 8 weight percent of the chewing gum. The oil includes a triglyceride, triacetin, and nicotine or a nicotine derivative. The triglyceride is present in an amount greater than or equal to 5 weight percent of the chewing gum. At least one example embodiment relates to a method of preparing a controlled-release nicotine chewing gum.

An oral pouch product includes an outer wrapper defining a cavity and an inner filling material in the cavity. The outer wrapper includes a hydrophobic material or an elastomeric material. The inner filling material includes a dry mixture and a liquid mixture. The dry mixture includes a cellulosic material. The liquid mixture includes a triglyceride and liquid nicotine dissolved in the triglyceride. The triglyceride is included in the oral pouch product in an amount of 10% to 30% by weight based on the weight of the oral pouch product.

Provided herein is a composition comprising nitrate for use in reducing or preventing oral dysbiosis and/or increasing oral eubiosis, by changing the bacterial composition and functions thereof of oral biofilms in a mammal, by decreasing the amount of disease-associated bacteria and increasing the amount of health-associated bacteria, thereby getting an acute treatment or prevention with effects before 24 hours of a biofilm-mediated oral disease (e.g. caries, periodontal diseases—gingivitis, periodontitis or peri-implantitis—and halitosis), and wherein the composition is orally administered to the mammal and thereby increases the concentration of nitrate in the saliva of the mouth. The composition can also comprise a bacterial strain belonging to Rothia, Neisseria or Kingella genera, for use in increasing the nitrate-reduction capacity of a mammal.

The invention is directed to a composition comprising a green tea flower extract and methods for making and using the composition in the management of a healthy body weight. The composition can comprise an aqueous alcohol extract of Camellia sinensis that is administered to a patient to provide a method for maintaining a healthy body weight.

Oral compositions provide delivery of cannabinoids to a subject. The oral compare chewable, fast- or slow-dissolving once placed in the mouth of a subject.

A soft chewable composition containing psyllium. The soft chewable composition can have from about 1% to about 55% psyllium and have a Hardness Parameter of greater than about 300 gf at a water activity of about 0.80 and less than about 10,000 gf at a water activity of about 0.50 as measured by the Texture Profile Analysis Method.