Disclosed is an elongate form medicament carrier carrying multiple distinct medicament dose portions. The said carrier has a first end, a second end, a central portion extending across the width of the elongate form medicament carrier, a first portion between the first end and the central portion and containing a medicament active, or a mixture of medicament actives, and a second portion between the second end and the central portion and containing a medicament active, or a mixture of medicament actives. The central portion of the carrier has a first end region, a unified length and a second end region, the unified length has a trailing end connecting to the first portion of the carrier via the first end region and connecting to the second portion of the carrier via the second end region, and the unified length has a leading end connecting to a loop of the central portion of the carrier.

Dry powder formulations for inhalation containing a combination of an anticholinergic, a long-acting beta.sub.2-adrenoceptor agonist, and a corticosteroid are useful for the prevention and/or treatment of an inflammatory and/or obstructive airways disease.

Described herein are dry powder compositions of liposomes, liposomal adjuvant or liposomal adjuvanted vaccines. Formulations containing a cryoprotectant can be converted to dry powders using, e.g., thin-film freeze-drying (TFFD). The composition may comprise a liposomal adjuvant, such as AS01.sub.B adjuvant, or also including an antigen, i.e., AS01.sub.B-adjuvanted vaccine compositions.

Isolated, pure, soluble isoform free recombinant human interferon alpha 2b (rhIFN α-2b). Methods of making the soluble isoform free rhIFN α-2b. Stable compositions and formulations of isoform free rhIFN α-2b are for administration generally for treatment and prevention of viral infections. In aspects, to prevent and/or minimize symptom(s) of viral infections such as respiratory infection(s) in a subject, in aspects SARS-COV2 infection.

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

The present invention includes a method of preventing and/or treating a fibrotic lung disease in a subject. In certain embodiments, the method comprises administering to the subject a thyroid receptor β-agonist. The invention further comprises compositions useful within the invention, as well as kits comprising compositions useful within the invention.

The present disclosure provides methods for treating a subject having a coronavirus infection by administering a composition that includes a sACE2 polypeptide to the lungs of a subject infected with a coronavirus. The sACE2 polypeptide includes the extracellular portion of the human ACE2 polypeptide and acts as a decoy, binding the spike (S) protein of coronavirus and thereby preventing the interaction of the S protein with membrane-associated ACE2 expressed on pulmonary cells, thus disrupting the infection process. The sACE2 polypeptide is derived from human ACE2, preventing potential immune reactions of the subject to the therapeutic polypeptide. The sACE2 polypeptide is administered locally to the site of the pathology, avoiding potential adverse effects of systemic delivery.

An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.

Dry powder compositions comprising biologically active antibodies or antibody fragments thereof are provided herein. In some aspects, the present disclosure includes methods of manufacturing these compositions and methods of using them in pulmonary administration or applying them to a tissue surface through a medical dry powder blower/sprayer/insufflator.

The invention relates to inhalable imatinib formulations, manufacture, and uses thereof.