The disclosure describes, in various example embodiments, a small arms or firearm projectile including a shell and a hemostatic material retained within the shell. The hemostatic material has a mechanical modulus above 25,000 Pa. In some embodiments, the shell includes a plurality of perforations. In some embodiments, the plurality of perforations are configured to provide, upon an impact of the projectile, fluid communication between the hemostatic material and the exterior of the shell via the plurality of perforations. In some embodiments, the hemostatic material includes a polymer core configured to provide a scaffold for inducing hemostasis in a local wound volume. In some embodiments, the projectile includes a contrasting agent. In some embodiments, the projectile includes a lubricating agent retained in the interior of the shell. In some embodiments, the projectile further includes 0.5 to 3 grains of Kaolin retained in the interior of the shell.

The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

The present disclosure relates to a pharmaceutical preparation having varenicline or a pharmaceutically acceptable salt thereof as an active ingredient. More particularly, it relates to an orally administered pharmaceutical preparation which allows limited use of a sweetening agent or a flavoring agent by effectively masking the unique taste of varenicline, particularly bitterness, which is a bitter and burning taste, and ensures convenience in taking the pharmaceutical preparation by being orally administrable without irritation, while containing a pharmaceutically effective amount of varenicline or a pharmaceutically acceptable salt thereof, and a method for preparing the same.

The present invention is drawn to novel topiramate compositions as well as methods for effecting weight loss, e.g., in the treatment of obesity and related conditions, including conditions associated with and/or caused by obesity per se. The present invention features an escalating dosing regimen adapted for the administration of topiramate and optionally a sympathomimetic agent such as phentermine or bupropion, in the treatment of obesity and related conditions.

A drug carrier carrying an active substance and a method preparing the same are provided. The method includes respectively dissolving a negatively charged polymer, sodium tripolyphosphate, and an active substance in a NaOH aqueous solution to increase the encapsulation rate of the active substance in the drug carrier.

A system for producing a microsphere includes a first raw material storing to store a first raw material is stored, a second raw material storing part to store a second raw material including a solvent, a biodegradable polymer, and a drug, an emulsion generating part to continuously form an emulsion including the first raw material of a continuous phase and the second raw material of a dispersed phase, a first solvent extracting and removing part to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere, and a second solvent extracting and removing part spaced apart from the first solvent extracting and removing part, to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere.

The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

The disclosure describes, in various example embodiments, a small arms or firearm projectile including a shell and a hemostatic material retained within the shell. The hemostatic material has a mechanical modulus above 25,000 Pa. In some embodiments, the shell includes a plurality of perforations. In some embodiments, the plurality of perforations are configured to provide, upon an impact of the projectile, fluid communication between the hemostatic material and the exterior of the shell via the plurality of perforations. In some embodiments, the hemostatic material includes a polymer core configured to provide a scaffold for inducing hemostasis in a local wound volume. In some embodiments, the projectile includes a contrasting agent. In some embodiments, the projectile includes a lubricating agent retained in the interior of the shell. In some embodiments, the projectile further includes 0.5 to 3 grains of Kaolin retained in the interior of the shell.

Pharmaceutical compositions and stable nano-suspensions comprising mifepristone and at least one pharmaceutically acceptable excipient, which exhibit enhanced bioavailability compared to the currently marketed or commercially available formulations. Manufacturing process and methods of use are also provided. The pharmaceutical compositions are used for prevention, treatment or prophylaxis of disorders in human patients in need thereof. Oral pharmaceutical compositions of mifepristone, methods for their administration, processes for thei r production, and use of these compositions are described for the treatment of diseases for which mifepristone is indicated.

The present invention relates in part a to multiparticulate sprinkle dosage form comprising duloxetine or a pharmaceutically acceptable salt thereof, having higher acid resistance as compared to commercially available delayed release formulations. It further relates to various methods of administering the said multiparticulate sprinkle dosage forms.