A61K9/2027

FORMULATIONS OF A FARNESOID X RECEPTOR AGONIST
20230120914 · 2023-04-20 ·

Described herein are pharmaceutical formulations of a farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, and methods of using such pharmaceutical formulations in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

SOLID COMPOSITIONS COMPRISING AN EGF(A) DERIVATIVE AND A SALT OF N-(8-(2-HYDROXYBENZOYL)AMINO)CAPRYLIC ACID

The invention relates to pharmaceutical compositions comprising a PCSK9 inhibitor, such as an EGF(A) peptide, and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

SUSTAINED RELEASE COMPOSITIONS OF 4-AMINOPYRIDINE

The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders.

METHODS OF MANUFACTURING ANAMORELIN TABLETS HAVING IMPROVED STABILITY
20220323430 · 2022-10-13 ·

Methods for reducing the formation of impurities in finished dosage forms of anamorelin hydrochloride, including formulations for improving such stability and analytical techniques for controlling impurity formation.

THERAPEUTIC COMPOUNDS AND METHODS

The invention provides a compound of formula (I):

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or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

MODIFIED RELEASE FORMULATIONS AND USES THEREOF

Provided are modified release compositions in a solid oral dosage form comprising racemic amisulpride, or pharmaceutically acceptable salts thereof, and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens.

DEUTERATED TRYPTAMINE DERIVATIVES AND METHODS OF USE
20230066286 · 2023-03-02 · ·

The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with a serotonin 5-HT.sub.2 receptor.

FAST DISSOLVING PHARMACEUTICAL COMPOSITIONS

The present disclosure relates to the field of pharmaceutical compositions. Furthermore, the present invention relates to an immediate release pharmaceutical composition in the form of a non-effervescent tablet composition comprising dasatinib and a gas generating agent.

Iniparib formulations and uses thereof

Disclosed herein are pharmaceutical compositions, formulations, and dosage forms and their use in the treatment of a cancer. Also disclosed herein are methods of treating a cancer in a subject in need thereof.

FOSPROPOFOL FORMULATIONS
20220323466 · 2022-10-13 ·

The present disclosure provides pharmaceutical compositions for oral administration of fospropofol, or pharmaceutically acceptable salts of fospropofol, as well as methods of oral administration of fospropofol.