A composition for preventing and treating heart dysfunction and its application thereof, including approximately 6-10% coenzyme Q10, approximately 40-45% Radix salviae Militiorrhizae and approximately 40-45% Radix notoginseng, which is prepared into an oral application such as tablets, capsules, granules or powders in sachets, pills, and oral solution. The extract of Radix salviae Militiorrhizae is a water-soluble extract of the root of Salvia miltiorrhiza Bunge and the powder of Radix notoginseng is a fine powder of the root of Panax notoginseng (Burk.). The composition can be prepared into a dietary supplement for improving heart function or a medicament for treating heart dysfunction by preventing heart failure, treating myocardial injury caused by hypoxia or reperfusion, treating abnormal heartbeat, treating palpitation, relieving pericardial edema, or treating palpitation and chest tightness caused by dysautonomia.

The present invention relates to a solid form, particularly to a 3D-printed immediate release solid dosage form (e.g. based on a pharmaceutical, nutraceutical, or food supplement composition). To overcome some of the solubility and disintegration problems inherited by 3D-printed solid dosage forms, the solid form comprises one or more channels, generally in the form of tubular passages or grooves, through the body of the solid form or the surface thereof.

Described herein are pharmaceutical compositions for the oral administration of nicotinamide, or a combination of nicotinamide and mesalazine, as well as methods of making such pharmaceutical compositions, and therapeutic methods for using them. The compositions comprise delayed-immediate release and delayed-extended release formulation of nicotinamide or a combination of nicotinamide and mesalazine.

An HS-25 tablet, an HS-25 solid dispersion composition, a preparation method therefor and usage thereof. The HS-25 tablet is made by using HS-25 and excipients for wet granulation, drying, granulating and tablet pressing.

The invention relates to a compound of formula (I) ##STR00001##
wherein A.sup.1, A.sup.2 and R.sup.1-R.sup.5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

An orodispersible formulation for contraception or hormone replacement therapy containing an estrogen and a progestogen that has sufficient hardness, disintegration time and friability.

A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug.

The present invention relates to an enteric coated pharmaceutical composition comprising a solid dispersion comprising regorafenib and at least one stabilizing agent outside of the solid dispersion, its process of preparation and its use for treating disorders.

Disclosed are compositions comprising grape seed extracts, in particular extracts with a proanthocyanidin content exceeding 95% by weight and a catechin and epicatechin content ≥5% and ≤15% by weight, which are useful to prevent or reduce the perception of stress symptoms, in particular the perception of stress among the male population.

A solid pharmaceutical composition for oral administration comprising raltegravir or its pharmaceutical acceptable salts and pH modifying agent.