The present invention concerns a transdermal therapeutic system, comprising a backing layer, which is not permeable for the active ingredient, and a matrix layer on one side of the backing layer, wherein the matrix layer contains at least one pressure sensitive adhesive and ketamine or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one pressure sensitive adhesive has free hydroxyl groups, as well as its use as medicament, in particular for the treatment of depression and pain.

In alternative embodiments, provided are products of manufacture and methods for using them, for the transdermal or transmucosal delivery of payloads and active agents such as pharmaceuticals, electrolytes, natural products and nutraceuticals. In alternative embodiments, provided are products of manufacture that utilize a nanoporous substrate coupled with controlled melt or solubilization of polymers for the delivery of the payloads and active agents or electrolytes transdermally.

The present invention relates to transdermal devices comprising prodrugs of anti-pyretic, analgesic, or anti-inflammatory molecules, methods of making such devices, and methods of use thereof for treating, preventing, minimizing, and/or diminishing fever or pain.

Transdermal delivery devices for the delivery of cannabidiol (CBD) are shown and described. In reservoir patch designs, a microporous, hydrophilic membrane and a backing define a reservoir that houses a mixture of CBD, a polar liquid, and a gelling agent. The hydrophilic membrane is coated with an amine-compatible silicone skin adhesive. In a monolithic design, a release liner is coated with a mixture of CBD and a PIB or amine-compatible silicone skin adhesive laminated to the backing material. In either design, the CBD may be provided as a pure compound or as a component of a cannabis oil.

The invention relates to a transdermal therapeutic system that includes a) a backing layer which faces away from the skin, is impermeable to the active substance, and is equipped with an adhesive layer for fixing onto the skin, b) an active substance reservoir which contains at least one active substance, c) a barrier layer which faces the skin, adjoins the active substance reservoir, is impermeable to the active substance and has at least one opening, and d) a removable protective layer, in which the backing layer which is equipped with the adhesive layer projects beyond the barrier layer on all sides.

The invention relates to a system containing: a transdermal therapeutic system (TTS); a cylindrical separating layer having an outer periphery and an inner periphery; and a backing layer, which is applied to the cylindrical separating layer and protrudes beyond the cylindrical separating layer over the entire periphery. The invention further relates to a system for improving the adhesion of a TTS, to the use of the system, and to a kit containing the system.

The present invention relates to a transdermal therapeutic system (1) comprising an active-substance carrier layer (2) having at least one active-substance-containing polymer matrix (3) applied to the active-substance carrier layer (2), said matrix comprising at least one pressure-sensitive adhesive and at least one pharmacologically active substance absorbable through human or animal skin, and an adhesive carrier layer (6) coated as completely as possible with an active-substance-free pressure-sensitive adhesive (7), said adhesive carrier layer being bonded by means of the active-substance-free pressure-sensitive adhesive (7) directly to the flat side of the active-substance carrier layer (2) facing away from the active-substance-containing polymer matrix (3),
wherein the adhesive carrier layer (6) projecting circumferentially beyond the edge of the active-substance carrier layer (2), wherein the system is characterized in that between the active-substance-containing polymer matrix (3) and the active-substance-free pressure-sensitive adhesive (7) there is a circumferential zone (4) having a reduced thickness of coating with the active-substance-containing polymer matrix (3) and/or with the active-substance-free pressure-sensitive adhesive (7). The invention further relates to the use of this transdermal therapeutic system and to a kit that contains it.

A method of preparing medical composition including hemp or Cannabis full plant extracts, cannabinoids, and one or more pharmaceutically acceptable excipients containing active pharmaceutical ingredients (APIs) can produce suppositories, patches, cream, lipstick or other skin care cosmetic. Cannabis, hemp plant chemicals and APIs can be delivered to one's bloodstream. The suppository composition is formulated for effective absorption through the mucosal membrane. The suppository is useful for the administration of medicine to treat pain, nausea, post-operative ileus, and/or inflammatory bowel diseases in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required.

Formulations comprising cycloserine compounds and one or more enteric materials in a solid dosage form, and uses thereof for treating and/or reducing the risk of a neuropsychiatric disorder or tuberculosis.

The present invention relates to transdermal devices comprising prodrugs of anti-pyretic, analgesic, or anti-inflammatory molecules, methods of making such devices, and methods of use thereof for treating, preventing, minimizing, and/or diminishing fever or pain.