A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance.

An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active molecule delivery system includes a first electrode, a plurality of microcells, and a porous conductive layer. The microcells are filled with a medium including active molecules.

A hydrophilic active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The system may be used to deliver/release hydrophilic active ingredients, generally.

A substantially solvent-free matrix layer containing ()-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.

Embodiments of the disclosure may include a medical device for releasing a medicament. The device may include a multi-layer patch. The patch may include a base layer configured to secure the patch to a body of a user and a medicament array located adjacent the base layer. The array may include a plurality of wells configured to release a quantity of medicament from the array to the body of the user. The device may also include a cover layer located on a side of the medicament array opposite the base layer and a pump operably coupled to the patch and configured to deliver a quantity of fluid to the patch.

An abuse deterrent transdermal patch comprising a multilaminate. The multilaminate can comprise a first layer comprising an opioid analgesic compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable pressure sensitive adhesive. The multilaminate can further comprise a second layer comprising an opioid antagonist, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adhesive. In addition, the multilaminate can further comprise a barrier layer disposed between the first and second layers.

A flexible drug delivery patch is described for non-invasively delivering macromolecular drugs directly to the circulatory system of a user. The patch includes multiple sealed reservoirs formed therein, the sealed reservoirs containing the macromolecular drugs which are entrapped within one of a dissolvable polymer matrix using one of nanoparticles or nanofibers or a thermo-responsive hydrogel. The macromolecular drugs being released from the sealed reservoirs and the entrapping material by activating one or more electrically addressable microheating units.

A multifunctional microstructure patch is provided. The multifunctional microstructure patch, according to one embodiment of the present invention, comprises: a base layer having an opening part formed in the center thereof; a plurality of microstructures formed on one surface of the base layer and comprising a first drug; and a cover layer detachably bonded on the other surface of the base layer along the periphery of the opening part, and formed so as to cover the opening part.

Transdermal therapeutic system and method of using the same for safely treating hypocholinergic disorders of the central nervous system such as Alzheimer type dementia. The transdermal therapeutic system comprises oxybutynin in combination with a cholinergic receptor agonist (CRA) such as xanomeline.

The present invention relates to an abuse deterrent transdermal patch, particularly transdermal patch for the transdermal administration of oxymorphone. The present invention also relates to processes for the preparation of the transdermal patches defined herein, as well as to the use of these patches for the treatment of pain.