A novel method of applying topical erectile dysfunction medicaments for controlled dispensing thereof through a condom or like prophylactic article is provided. Additionally, encompassed within this invention is the combination of an initial ingestion of a small dose of orally taken ED medicament for initial generation of nitric oxide followed by such a topical application. With such a method, the initial oral application metabolizes and runs its course while the topical application provides the needed dose of ED medicament. Once a sexual event is completed, the wearer may then remove the topical application article removing the topical delivery thereof in order to return to a flaccid state quickly and easily. Such an article and method thus reduces the propensity for potentially damaging excessive erection states and provides a more reliable dosing regimen for more effective and safe implementation of such an ED medicament program.

Devices and systems for delivering an agent to the skin of a subject comprise an anhydrous agent (e.g. a pharmaceutical agent or a cosmetic agent), and an anhydrous heating component and a reservoir containing a solvent. When in use solvent released from the reservoir hydrates the anhydrous agent to produce a solution and hydrates the anhydrous heating component which reacts exothermically thereby heating the solution. The devices and systems enable the transdermal delivery of pharmaceutical and cosmetic agents.

Modular transdermal delivery system components are provided that are assembled to provide a modular transdermal drug delivery system for the administration of a pharmacologically active agent for treating insomnia, anxiety, or both insomnia and anxiety. The components include: an upper module with an outer backing layer, a pressure-sensitive adhesive (PSA) layer laminated thereto, and a removable release liner; and at least two lower modules with a porous drug reservoir layer capable of adhering to the PSA layer of the upper module and loaded with a pharmaceutical formulation containing an effective amount of the pharmacologically active agent, with a skin-contact adhesive affixed to the drug reservoir layer. The lower modules differ from each other in at least one respect, e.g., with respect to thickness, drug reservoir volume, active agent, or dosage, such that prior to use the upper module any lower module can be selected and assembled with the upper module to provide a laminated transdermal delivery system. Related systems and methods of manufacture and use are also provided.

Modular transdermal delivery system components are provided that are assembled to provide a modular transdermal drug delivery system for the administration of a pharmacologically active agent for treating pain, inflammation, or both pain and inflammation. The components include: an upper module with an outer backing layer, a pressure-sensitive adhesive (PSA) layer laminated thereto, and a removable release liner; and at least two lower modules with a porous drug reservoir layer capable of adhering to the PSA layer of the upper module and loaded with a pharmaceutical formulation containing an effective amount of the pharmacologically active agent, with a skin-contact adhesive affixed to the drug reservoir layer. The lower modules differ from each other in at least one respect, e.g., with respect to thickness, drug reservoir volume, active agent, or dosage, such that prior to use the upper module any lower module can be selected and assembled with the upper module to provide a laminated transdermal delivery system. Related systems and methods of manufacture and use are also provided.

A composition comprising an oxidoreductase enzyme and a substrate for the enzyme for use in treating or preventing biofilm formation by a population of pathogenic bacteria. The composition can be incorporated into a wound dressing for use in promoting wound healing.

The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and characterized by a considerably increased utilization of the active substance.

An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including active molecules. The microcells include an opening, and the opening is spanned by a porous diffusion layer. The microcell arrays may be loaded with different active ingredients, thereby providing a mechanism to deliver different, or complimentary, active ingredients on demand.

An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium for delivering the active molecules. In some embodiments the medium includes active molecules dispersed in a first charged phase as well as a second phase that is oppositely charged or uncharged and immiscible with the first phase. Where the medium includes a charged first phase, the first phase can be moved adjacent to, or away from, the porous diffusion layer in order to control the rate of delivery.

An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including an active ingredient and charged or magnetic particles. The microcells include an opening, and the opening is spanned by a porous diffusion layer. Because the porous diffusion layer can be blocked with the charged or magnetic particles, the rate at which the active ingredient is dispensed can be controlled with an electric or magnetic field, respectively.