The application provides a composition comprising cannadibiol, a fatty acid component comprising a balanced amount of omega-3 and omega-6 fatty acids, and a sterol and optionally a vitamin E compound. The composition has been shown to be well tolerated and supportive when administered to subjects suffering from or at risk of developing a skin disorder and/or an inflammatory condition, such as atopic dermatitis. Also disclosed are methods of supporting the immune system and skin health of a subject involving administration of the compositions.

A method of reducing symptoms of neurodegenerative disease in a human is provided. The method comprises applying to the human a solution or salve to at least one of the skin, the mouth, the nasal cavities, the lungs, the eyes, or the vagina of the human. The applied solution or salve comprises an effective amount of an isomerized or conjugated linoleic acid cation salt having a conjugated diene for at least a measurable improvement in the movement or mental acuity of the human and a structure of -C=C-C=C-. The measurable improvement in the movement or mental acuity of the human is within 4-6 weeks of the applying of the solution or salve. A method of making the conjugated diene and a device for measuring the reduction of systems is also provided.

A method of reducing symptoms of neurodegenerative disease in a human is provided. The method comprises applying to the human a solution or salve to at least one of the skin, the mouth, the nasal cavities, the lungs, the eyes, or the vagina of the human. The applied solution or salve comprises an effective amount of an isomerized or conjugated linoleic acid cation salt having a conjugated diene for at least a measurable improvement in the movement or mental acuity of the human and a structure of -C=C-C=C-. The measurable improvement in the movement or mental acuity of the human is within 4-6 weeks of the applying of the solution or salve. A method of making the conjugated diene and a device for measuring the reduction of systems is also provided.

A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.

A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.

An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

Disclosed are compounds of Formula (I): or a salt thereof, wherein: R.sub.1, R.sub.2, R.sub.4, R.sub.5, R.sub.6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferatve disorders, such as cancer.

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Provided herein are microbubble compositions comprising nitro-fatty acids and/or esters thereof, such as amphiphilic esters or allyl esters thereof. Also provided are methods of reducing local inflammation at a site in a patient comprising delivering the microbubbles to a site of inflammation in the patient and applying ultrasound to the microbubbles. The methods may be used to treat fibrosis or cancer.