The present invention provides a dietary supplement that contains necessary ingredients for neurological protection and neurogenesis in one formulation. This dietary supplement comprises combinations of vitamins and substances that are naturally endogenous to the brain, are known to decline with age, injury and disease and are essential for membrane structure, mitochondrial respiration and stem cell differentiation.

The invention related to the use of carbamate-β-phenylethanolamine analogues for up-regulating of LDL receptors, facilitating uptake of extracellular LDL cholesterol and reducing intercellular total cholesterol. It also related to use of carbamate-β-phenylethanolamine analogues and statins or other lipid lowering agents as combined therapies for synergic effects in lowering LDL cholesterol as well as for reducing adverse effects.

The invention related to the use of carbamate-β-phenylethanolamine analogues for up-regulating of LDL receptors, facilitating uptake of extracellular LDL cholesterol and reducing intercellular total cholesterol. It also related to use of carbamate-β-phenylethanolamine analogues and statins or other lipid lowering agents as combined therapies for synergic effects in lowering LDL cholesterol as well as for reducing adverse effects.

An antimicrobial (anticandidal, antibacterial, antifungal) and antiviral composition which repels insects such as flies, mosquitoes and ticks. The composition includes poloxamer, boron compound, ethyl butyl acetylaminopropionate and preferably hydrogen peroxide. The present composition is a composition which can be applied in different forms via oral, nasal, ophthalmic, otic, local, ventricle, vaginal, rectal, dermal, intravenous, intramuscular, subcutaneous and intradermal route.

An antimicrobial (anticandidal, antibacterial, antifungal) and antiviral composition which repels insects such as flies, mosquitoes and ticks. The composition includes poloxamer, boron compound, ethyl butyl acetylaminopropionate and preferably hydrogen peroxide. The present composition is a composition which can be applied in different forms via oral, nasal, ophthalmic, otic, local, ventricle, vaginal, rectal, dermal, intravenous, intramuscular, subcutaneous and intradermal route.

This invention relates to compositions and methods for the transplantation of GABAergic neurons. GABAergic neurons and compositions comprising the same according to the present invention may be used as cell-based therapies for restoring or reinforcing central inhibition in the nervous system of a subject and for the treatment of neurological conditions, diseases and disorders associated with impaired or aberrant neural function. In a preferred embodiment, the transplant composition comprise of GABAergic neurons, a GFR-alpha agonist, and at least one cell death inhibitor, and that the GABAergic neurons are generated by differentiating pluripotent stem cells, multipotent stem cells, or progenitor cells.

This invention relates to compositions and methods for the transplantation of GABAergic neurons. GABAergic neurons and compositions comprising the same according to the present invention may be used as cell-based therapies for restoring or reinforcing central inhibition in the nervous system of a subject and for the treatment of neurological conditions, diseases and disorders associated with impaired or aberrant neural function. In a preferred embodiment, the transplant composition comprise of GABAergic neurons, a GFR-alpha agonist, and at least one cell death inhibitor, and that the GABAergic neurons are generated by differentiating pluripotent stem cells, multipotent stem cells, or progenitor cells.

The invention related to polynucleotides comprising an open reading frame of linked nucleosides encoding therapeutic proteins or variant therapeutic proteins, isoforms thereof, functional fragments thereof, and fusion proteins comprising therapeutic proteins. In some embodiments, the open reading frame is sequence-optimized. The invention also relates to methods of treating muscular dystrophies.

The invention related to polynucleotides comprising an open reading frame of linked nucleosides encoding therapeutic proteins or variant therapeutic proteins, isoforms thereof, functional fragments thereof, and fusion proteins comprising therapeutic proteins. In some embodiments, the open reading frame is sequence-optimized. The invention also relates to methods of treating muscular dystrophies.

The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of retinoids and retinoid-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.