We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

Multi-parameter water analysis system with a water parameter sensing device configured to wirelessly provide detector data and a smart phone displayable indicator of water analysis test results that are calculated by an analysis application that is updateable via a cloud-based data resource to account for a manufacturing change in indicator chemistry and/or an improvement in test result display. The water parameter sensing device includes an optical sensing apparatus configured to detect light from each of a plurality of indicators for different parameters when the indicator and a chemical parameter are exposed to each other, a processor to process information of the detected light, and wireless communication circuitry for communicating detector data based on the information about the detected light to a remote device. Social networking of water quality data allows sharing to other users.

An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Systems, methods, and software that measure a plurality of error values each related to a different condition of an aquatic environment monitoring system including a degradation in a chemical indicator due to photo-aging, a degradation in a chemical indicator due to water-aging, a physical contamination of a chemical indicator, an illumination imbalance related to an optical reader, a degradation of a light source of an optical reader, a contamination in water between an optical reader and a chemical indicator, a displacement due to friction between a chemical indicator apparatus and a monitoring unit, an error intrinsic in a chemical indicator, and an error in distance between a chemical indicator and an optical reader. The plurality of error values are used to determine a confidence level that is compared to a threshold value associated with the monitoring system. A correction instruction is generated for correcting one or more of the conditions.

The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Multi-parameter water analysis system with a holder removably engageable in an enclosable water chamber having an inlet and outlet in line with plumbing of an aquatic environment and allowing water from the aquatic environment to enter the enclosable water chamber for a chemical indicator of the holder to indicate a physical change via an optical reader, the holder configured to move with respect to the optical reader at least in part due to a motive force provided by the flow of water from the inlet in the enclosable water chamber.

A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.