Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

The embodiments disclose a method including creating a dual product vaporizer for use in vaping two different types of products at the same time, atomizing the two different types of products using two heaters for allowance of different burn temperatures for each of the two different types of products, wherein the two heaters are configured to operate at two different temperatures, wherein the two heaters are configured to operate at the same temperature, wherein the dual product vaporizer is configured to operate with only one product cartridge inserted, using at least one rechargeable battery to power the two heaters and an LED light battery indicator, and using two individual draw holes for drawing atomized product vapors from two individual product cartridges at the same time.

A liquid nicotine formulation for an aerosol-generating system is provided, the nicotine formulation including: one or more water-miscible polyhydric alcohols, the nicotine formulation having a water-miscible polyhydric alcohol content of greater than or equal to about 5 percent by weight; and one or more low molar mass metal salts, the one or more low molar mass metal salts being selected from the group consisting of metal cinnamates, metal cycloheptanecarboxylates, metal levulinates, metal propanoates, metal stearates, and metal undecanoates. An aerosol-generating article and an aerosol-generating system are also provided.

A liquid nicotine formulation for an aerosol-generating system is provided, the nicotine formulation including: one or more water-miscible polyhydric alcohols, the nicotine formulation having a water-miscible polyhydric alcohol content of greater than or equal to about 5 percent by weight; and one or more low molar mass metal salts, the one or more low molar mass metal salts being selected from the group consisting of metal cinnamates, metal cycloheptanecarboxylates, metal levulinates, metal propanoates, metal stearates, and metal undecanoates. An aerosol-generating article and an aerosol-generating system are also provided.

A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.

A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.

A liquid nicotine formulation for an aerosol-generating system is provided, the liquid nicotine formulation including: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20° C. of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20° C. of less than or equal to about 5 mg/ml, the liquid nicotine formulation having a water-insoluble, water-immiscible solvent content of greater than or equal to about 2 percent by weight. A cartridge containing the liquid nicotine formulation, and an aerosol-generating system, are also provided.

A liquid nicotine formulation for an aerosol-generating system is provided, the liquid nicotine formulation including: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20° C. of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20° C. of less than or equal to about 5 mg/ml, the liquid nicotine formulation having a water-insoluble, water-immiscible solvent content of greater than or equal to about 2 percent by weight. A cartridge containing the liquid nicotine formulation, and an aerosol-generating system, are also provided.

Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.