Compositions and methods for increasing stress response and improving health and slowing the aging process in a user. A composition includes one or more of a first group consisting of milk thistle, ashwagandha, green tea, bacopa monnieri, and turmeric. The composition includes one or more of a second group consisting of acetyl-L-carnitine, quercetin, lipoic acid, coenzyme Q10, cysteine, and grape. The composition includes one or more of a third group consisting of wasabi, theacrine, copper, nicacin, cysteine, and olive extract.

Compositions and methods for increasing stress response and improving health and slowing the aging process in a user. A composition includes one or more of a first group consisting of milk thistle, ashwagandha, green tea, bacopa monnieri, and turmeric. The composition includes one or more of a second group consisting of acetyl-L-carnitine, quercetin, lipoic acid, coenzyme Q10, cysteine, and grape. The composition includes one or more of a third group consisting of wasabi, theacrine, copper, nicacin, cysteine, and olive extract.

An oral product in the form of an edible film is provided herein. The edible film can include a binder in an amount of at least about 30 percent by weight; a plasticizer in an amount of at least about 5 percent by weight; and an active agent, wherein the edible film is orally dissolvable. The edible film can also be used as a component of another oral product, e.g., a fleece-based pouched product. The edible film can form a coating on a portion of an interior or exterior surface of a fleece-based pouched product.

An oral product in the form of an edible film is provided herein. The edible film can include a binder in an amount of at least about 30 percent by weight; a plasticizer in an amount of at least about 5 percent by weight; and an active agent, wherein the edible film is orally dissolvable. The edible film can also be used as a component of another oral product, e.g., a fleece-based pouched product. The edible film can form a coating on a portion of an interior or exterior surface of a fleece-based pouched product.

An oral product configured for oral use is provided herein, the oral product including: at least one sugar substitute in an amount from about 25% to about 45% by weight, based on the total weight of the oral product; a gum in an amount from about 35% to about 55% by weight, based on the total weight of the oral product; a basic amine; and an organic acid, an alkali metal salt of an organic acid, or a combination thereof; wherein the organic acid has a log P value of from about 1.0 to about 12.0; wherein at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both; and wherein the oral product is in the form of a pastille.

An oral product configured for oral use is provided herein, the oral product including: at least one sugar substitute in an amount from about 25% to about 45% by weight, based on the total weight of the oral product; a gum in an amount from about 35% to about 55% by weight, based on the total weight of the oral product; a basic amine; and an organic acid, an alkali metal salt of an organic acid, or a combination thereof; wherein the organic acid has a log P value of from about 1.0 to about 12.0; wherein at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both; and wherein the oral product is in the form of a pastille.

The disclosure provides a multi-layered tablet configured for oral use, the tablet including a first layer including an effervescent composition and a second layer including a non-effervescent composition. The effervescent composition includes an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; and at least one active ingredient. The non-effervescent composition includes one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; a binder; and a second active ingredient.

The disclosure provides a multi-layered tablet configured for oral use, the tablet including a first layer including an effervescent composition and a second layer including a non-effervescent composition. The effervescent composition includes an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; and at least one active ingredient. The non-effervescent composition includes one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; a binder; and a second active ingredient.

Systems and methods for synchronizing the administration of compounds with the human body's natural circadian rhythms and addiction rhythms to counteract symptoms when they are likely to be at their worst by using an automated and preprogrammable transdermal or other drug administration system.

Systems and methods for synchronizing the administration of compounds with the human body's natural circadian rhythms and addiction rhythms to counteract symptoms when they are likely to be at their worst by using an automated and preprogrammable transdermal or other drug administration system.