The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I):

##STR00001##

(wherein
R.sup.6 and R.sup.7 may be the same or different and each represent a hydrogen atom or the like,
R.sup.8, R.sup.9, R.sup.10, and R.sup.11 may be the same or different and each represent a hydrogen atom or the like,
R.sup.1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and
R.sup.3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I):

##STR00001##

(wherein
R.sup.6 and R.sup.7 may be the same or different and each represent a hydrogen atom or the like,
R.sup.8, R.sup.9, R.sup.10, and R.sup.11 may be the same or different and each represent a hydrogen atom or the like,
R.sup.1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and
R.sup.3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

The present invention relates to a preservative free ophthalmic pharmaceutical formulation for topical administration containing a therapeutically effective quantity of Brimonidine or ophthalmological acceptable salts thereof alone or in combination with a therapeutically effective quantity of Timolol or ophthalmological acceptable salts thereof, to be used for the treatment of ocular hypertension and glaucoma.

The present invention relates to a preservative free ophthalmic pharmaceutical formulation for topical administration containing a therapeutically effective quantity of Brimonidine or ophthalmological acceptable salts thereof alone or in combination with a therapeutically effective quantity of Timolol or ophthalmological acceptable salts thereof, to be used for the treatment of ocular hypertension and glaucoma.

The present invention relates to a preservative free ophthalmic pharmaceutical formulation for topical administration containing a therapeutically effective quantity of Brimonidine or ophthalmological acceptable salts thereof alone or in combination with a therapeutically effective quantity of Timolol or ophthalmological acceptable salts thereof, to be used for the treatment of ocular hypertension and glaucoma.

An aqueous ophthalmic composition, comprising: a therapeutically effective amount of brimonidine or their salts thereof; a therapeutically effective amount of brinzolamide or their salts thereof; buffers at a concentration that is at least about 0.05% w/v to 5.0% w/v of the ophthalmic composition; a preservative and; pharmaceutically acceptable excipients, wherein the pH of said composition is less than 8.0.

An aqueous ophthalmic composition, comprising: a therapeutically effective amount of brimonidine or their salts thereof; a therapeutically effective amount of brinzolamide or their salts thereof; buffers at a concentration that is at least about 0.05% w/v to 5.0% w/v of the ophthalmic composition; a preservative and; pharmaceutically acceptable excipients, wherein the pH of said composition is less than 8.0.

An aqueous ophthalmic composition, comprising: a therapeutically effective amount of brimonidine or their salts thereof; a therapeutically effective amount of brinzolamide or their salts thereof; buffers at a concentration that is at least about 0.05% w/v to 5.0% w/v of the ophthalmic composition; a preservative and; pharmaceutically acceptable excipients, wherein the pH of said composition is less than 8.0.

Provided herein are compositions and methods for treating, reducing, preventing, inhibiting, mitigating, ameliorating, or slowing ocular replication or infections, such as viral conjunctivitis. Certain embodiments of the present disclosure relate to product combinations that include one or more ribonuclease, such as ranpirnase, or a variant, derivative, analogue, fragment, or pharmaceutically acceptable salt thereof, and one or more additional therapeutic agent, such as a vasoconstrictor, an antibiotic, an immunomodulatory compound, or a steroid.

Provided herein are compositions and methods for treating, reducing, preventing, inhibiting, mitigating, ameliorating, or slowing ocular replication or infections, such as viral conjunctivitis. Certain embodiments of the present disclosure relate to product combinations that include one or more ribonuclease, such as ranpirnase, or a variant, derivative, analogue, fragment, or pharmaceutically acceptable salt thereof, and one or more additional therapeutic agent, such as a vasoconstrictor, an antibiotic, an immunomodulatory compound, or a steroid.