The present disclosure is directed to methods for treating immunological diseases and disorders with upadacitinib. The methods include adjusting the dose of upadacitinib in patients with severe renal impairment, in patients concurrently receiving a strong inhibitor of cytochrome P450 3A4 (CYP3A4), and in adult patients 65 years of age and older.

The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. The compounds of this disclosure also relate to ##STR00001##
The use of these compounds as radio— and chemo—protectors is also described.

Methods for preventing or treating diastolic dysfunction in an individual comprising administering to an individual in need of said prevention or treatment a therapeutically effective amount of a (gamma) γ-secretase modulator or inhibitor, compositions comprising a (gamma) γ-secretase modulator or inhibitor for use in treatment of diastolic dysfunction and pharmaceutical compositions comprising same.

Methods for preventing or treating diastolic dysfunction in an individual comprising administering to an individual in need of said prevention or treatment a therapeutically effective amount of a (gamma) γ-secretase modulator or inhibitor, compositions comprising a (gamma) γ-secretase modulator or inhibitor for use in treatment of diastolic dysfunction and pharmaceutical compositions comprising same.

The invention relates to a particular substituted heterocycle fused gamma-carboline, the compound of Formula I, and new methods and uses pertaining thereto, and pharmaceutical compositions thereof, such as methods of use in the treatment of diseases involving the 5-HT receptor, the serotonin transporter (SERT), and/or pathways involving dopamine D.sub.2 receptor signaling, sodium channel activity, and/or norepinephrine transporter activity.

The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Described herein are methods and pharmaceutical formulations for treating dry eye disease.

Described herein are methods and pharmaceutical formulations for treating dry eye disease.

Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

##STR00001##