An applicator for medical-use liquids includes a handle having a hollow cylindrical member, a container incorporated in the cylindrical member, and a cleaving member of the container; and an applying section having an attachment plate of an application pad (integrally) fixed to a lower end of the cylindrical member to be an inclined cross section and the application pad fixed to the attachment plate. The attachment plate has a bank section formed thick at a peripheral edge, a base bottom section formed as a recess in a center, an inclined outflow hole opened inclinedly with respect to the base bottom section near the base bottom section center such that the solution flows out toward an attachment plate distal end direction, and a weir provided in an arcuate or crescent shape. A flow of the solution flowed out from the inclined outflow hole is reversed to flow backward by the weir.

This invention relates to xanthohumol-based compositions, yielded in a hot-melt extrusion process (HME) using one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers, such as selected from hydroxypropylmethyl-cellulose (HPMC), a vinylpyrrolidone-vinyl acetate copolymer, and combinations thereof. The present invention also relates to topical and oral formulations comprising such extruded xanthohumol-based compositions, as well as the use of one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers in a hot-melt extrusion process of xanthohumol.

This invention relates to xanthohumol-based compositions, yielded in a hot-melt extrusion process (HME) using one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers, such as selected from hydroxypropylmethyl-cellulose (HPMC), a vinylpyrrolidone-vinyl acetate copolymer, and combinations thereof. The present invention also relates to topical and oral formulations comprising such extruded xanthohumol-based compositions, as well as the use of one or more water-soluble nutritionally and/or cosmetically acceptable thermoplastic polymers in a hot-melt extrusion process of xanthohumol.

A method for administering an active agent to a pleura of a patient includes preparing a composition including a foamable liquid and the active agent, incorporating a gas into the foamable liquid to create a foam containing the active agent, introducing the foam into a pleural cavity of the patient defined by the pleura, and contacting the pleura with the foam. A method of pleurodesis includes introducing a composition into a pleural cavity defined by pleurae of a patient, the composition including a foamable liquid and an active agent capable of causing inflammation and/or adhesion of the pleurae. A composition for treating a pleura of a patient includes a liquid component including a biocompatible composition having a viscosity which increases in response to an increase in temperature, and an active agent capable of causing inflammation and/or adhesion of the pleura.

An ethanol-free antimicrobial treatment composition, comprising: an antimicrobially effective amount of polyvinylpyrrolidone iodine (PVPI) ranging from 1.0% to a dilution-accommodating 3.5%; an inclusion of at least one room-temperature, water-insoluble, viscous membrane permeation-enhancing essential flavoring oil selected from the group consisting of: menthol in an amount of at least 15% by weight, spearmint oil in an amount of between 30% to 55% by weight, peppermint oil in an amount of at least 10% by weight, carvone, methyl salicylate, anethole, thymol, eugenol, coolants and cinnamic aldehydes; a Stevia sweetener pre-mixed in a microemulsion solution of dimethyl sulfoxide (DMSO); and

ion-free distilled water.

An ethanol-free antimicrobial treatment composition, comprising: an antimicrobially effective amount of polyvinylpyrrolidone iodine (PVPI) ranging from 1.0% to a dilution-accommodating 3.5%; an inclusion of at least one room-temperature, water-insoluble, viscous membrane permeation-enhancing essential flavoring oil selected from the group consisting of: menthol in an amount of at least 15% by weight, spearmint oil in an amount of between 30% to 55% by weight, peppermint oil in an amount of at least 10% by weight, carvone, methyl salicylate, anethole, thymol, eugenol, coolants and cinnamic aldehydes; a Stevia sweetener pre-mixed in a microemulsion solution of dimethyl sulfoxide (DMSO); and

ion-free distilled water.

Wound-care composition and method of use. The composition comprises: a substrate; potassium alum; and urea. The potassium alum makes up 10.27 wt. % of the composition within a tolerance of +/- 50%; and the urea makes up 0.12 wt. % of the composition within a tolerance of +/- 50%. The method comprises applying the composition to a wound on a non-human animal.

Wound-care composition and method of use. The composition comprises: a substrate; potassium alum; and urea. The potassium alum makes up 10.27 wt. % of the composition within a tolerance of +/- 50%; and the urea makes up 0.12 wt. % of the composition within a tolerance of +/- 50%. The method comprises applying the composition to a wound on a non-human animal.

The invention concerns removing advanced glycation end products from a bodily fluid by contacting the bodily fluid with a sorbent.

The invention concerns removing advanced glycation end products from a bodily fluid by contacting the bodily fluid with a sorbent.