This disclosure is directed to an ophthalmic formulation for dry eye and other ocular indications that provides long-lasting benefits. The formulations described herein provide durable relief and last two to ten longer on the eye than currently marketed products. The disclosure also provides methods of alleviating the symptoms of dry eye, methods for delivering ophthalmic pharmaceuticals, and methods of manufacture of the long-lasting ophthalmic formulations.

Disclosed are methods and topical compositions for applying bacteria to skin, scalp and hair. The topical compositions include bacteria in a suitable base vehicle comprising honey for applying the bacteria to skin, scalp and hair. The base vehicle may include additional components such as, but not limited to, plant-based products, micro-nutrients, emollients and plant-sourced emulsifiers, and anti-oxidants, among other components. The topical compositions may be utilized in methods for treating and/or preventing skin, scalp, and hair conditions such as, but not limited to, dry skin, dry scalp, dandruff, psoriasis, cradle cap, seborrheic dermatitis, and/or eczema.

Disclosed are methods and topical compositions for applying bacteria to skin, scalp and hair. The topical compositions include bacteria in a suitable base vehicle comprising honey for applying the bacteria to skin, scalp and hair. The base vehicle may include additional components such as, but not limited to, plant-based products, micro-nutrients, emollients and plant-sourced emulsifiers, and anti-oxidants, among other components. The topical compositions may be utilized in methods for treating and/or preventing skin, scalp, and hair conditions such as, but not limited to, dry skin, dry scalp, dandruff, psoriasis, cradle cap, seborrheic dermatitis, and/or eczema.

A food supplement for helping alleviate the side effects of cancer and cancer treatments is disclosed which is formed from a mixture including at least one edible oil, at least one chopped fruit or fruit paste; at least one ground nut or seed meal or ground nut or seed butter; and honey. The food supplement has a volume of less than three cubic inches and provides at least 100 kilocalories of energy, making it small in volume but with a high energy density. The food supplement can have a high fat content which can make the food supplement moist and easy to eat while providing the necessary calories need for patients combatting cancer and undergoing cancer treatments who often have a severely reduced appetite.

A food supplement for helping alleviate the side effects of cancer and cancer treatments is disclosed which is formed from a mixture including at least one edible oil, at least one chopped fruit or fruit paste; at least one ground nut or seed meal or ground nut or seed butter; and honey. The food supplement has a volume of less than three cubic inches and provides at least 100 kilocalories of energy, making it small in volume but with a high energy density. The food supplement can have a high fat content which can make the food supplement moist and easy to eat while providing the necessary calories need for patients combatting cancer and undergoing cancer treatments who often have a severely reduced appetite.

A food supplement for helping alleviate the side effects of cancer and cancer treatments is disclosed which is formed from a mixture including at least one edible oil, at least one chopped fruit or fruit paste; at least one ground nut or seed meal or ground nut or seed butter; and honey. The food supplement has a volume of less than three cubic inches and provides at least 100 kilocalories of energy, making it small in volume but with a high energy density. The food supplement can have a high fat content which can make the food supplement moist and easy to eat while providing the necessary calories need for patients combatting cancer and undergoing cancer treatments who often have a severely reduced appetite.

The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

Described, among other things, are dosage forms for administration to a subject, the dosage forms having at least six ingredients are selected are from the group consisting of clove powder, rutin, hesperidin, baicalin, sulforaphane, moringa leaf extract, rosmarinic acid, guava leaf extract, Panax notoginseng, EGCG, propolis, coriander extract, cardamom extract, cinnamaldehyde, chlorogenic acid, caper fruit, vescalagin, nutmeg extract, and naringenin. The dosage forms can serve as inhibitors of quorum sensing by infectious agents. The described combinations of selected natural products have the ability to inhibit quorum sensing. Quorum sensing is a means by which bacteria and viruses communicate with each other and induce virulence in the body. This combination of natural products is preferably included in nutraceutical formulations in order to promote human immune health.