Described herein are combined fungal compositions for treating, prophylaxis of, or ameliorating symptoms of one or more adverse reactions triggered by an infectious disease or condition that causes an inflammatory response. In one aspect the composition comprises an aqueous or solid fraction of Trametes versicolor and Fomitopsis officinalis mycelium, fermented substrates thereof, or combinations thereof.

The invention relates to the field of health food technologies, and particularly to a composition and an application thereof in preparing a product for protecting mitochondria. The invention provides a composition, the raw materials of which include Haematococcus pluvialis, Lycium ruthenicum, Cordyceps militaris and nicotinamide. The composition has the effects of improving an oxidative stress level under a mitochondrial dysfunction and delaying mitochondrion-related aging. Compared with a single constituent, constituents in the composition cooperate with each other to produce a synergistic effect, which significantly improves an effect of protecting a mitochondrial function.

The invention relates to the field of health food technologies, and particularly to a composition and an application thereof in preparing a product for protecting mitochondria. The invention provides a composition, the raw materials of which include Haematococcus pluvialis, Lycium ruthenicum, Cordyceps militaris and nicotinamide. The composition has the effects of improving an oxidative stress level under a mitochondrial dysfunction and delaying mitochondrion-related aging. Compared with a single constituent, constituents in the composition cooperate with each other to produce a synergistic effect, which significantly improves an effect of protecting a mitochondrial function.

Provided is the composition capable of effectively exerting an effect on a change in a hormone balance. A composition for inhibiting the decrease in endogenous testosterone and/or dihydrotestosterone, the composition comprising Cordyceps militaris derived from Samia cynthia ricini and/or its extract is prepared.

Provided is the composition capable of effectively exerting an effect on a change in a hormone balance. A composition for inhibiting the decrease in endogenous testosterone and/or dihydrotestosterone, the composition comprising Cordyceps militaris derived from Samia cynthia ricini and/or its extract is prepared.

A method for microbial fermentation of botanicals includes steps of: fermenting with wall-breaking fungi, and then fermenting with probiotics. The wall-breaking fungi are wood-grown fungi and/or Cordyceps. The method can effectively destroy the cell wall of the botanical, promote release of effective ingredients of the botanical and improve utilization rate of the botanical. In addition, due to fermenting with the wall-breaking fungi, the botanical medicine also contains the active ingredients of the wall-breaking fungi. Thereby the efficacy of the botanical is increased.

A method for microbial fermentation of botanicals includes steps of: fermenting with wall-breaking fungi, and then fermenting with probiotics. The wall-breaking fungi are wood-grown fungi and/or Cordyceps. The method can effectively destroy the cell wall of the botanical, promote release of effective ingredients of the botanical and improve utilization rate of the botanical. In addition, due to fermenting with the wall-breaking fungi, the botanical medicine also contains the active ingredients of the wall-breaking fungi. Thereby the efficacy of the botanical is increased.

A composition for treating opioid withdrawal and method of manufacture and administration of the composition creates a synergistic combination of cannabinoids, terpenoids, herbs, and medicinal mushrooms that help to eliminate the symptoms of opioid withdrawal by creating a medicinal entourage. The composition combines: between about 2.5 to 100 milligrams of a cannabinoid, between about 0.084 to 33.6 milligrams of a terpenoid, between about 0.5 to 3000 milligrams of an herb, and between about 25 to 2500 milligrams of a medicinal mushroom. The composition is orally administered in a lipid-enclosed capsule form. The terpenoid has a lipophilic nature that enhances the bioavailability of the cannabinoid. The herb works with the body's endocannabinoid system to enhance pain relief capacity of the cannabinoid, so as to help inhibit symptoms of opioid withdrawal. The medicinal mushroom comprises a psychedelic drug that creates a therapeutic effect with the cannabinoid to inhibit symptoms of opioid withdrawal.

A composition for treating opioid withdrawal and method of manufacture and administration of the composition creates a synergistic combination of cannabinoids, terpenoids, herbs, and medicinal mushrooms that help to eliminate the symptoms of opioid withdrawal by creating a medicinal entourage. The composition combines: between about 2.5 to 100 milligrams of a cannabinoid, between about 0.084 to 33.6 milligrams of a terpenoid, between about 0.5 to 3000 milligrams of an herb, and between about 25 to 2500 milligrams of a medicinal mushroom. The composition is orally administered in a lipid-enclosed capsule form. The terpenoid has a lipophilic nature that enhances the bioavailability of the cannabinoid. The herb works with the body's endocannabinoid system to enhance pain relief capacity of the cannabinoid, so as to help inhibit symptoms of opioid withdrawal. The medicinal mushroom comprises a psychedelic drug that creates a therapeutic effect with the cannabinoid to inhibit symptoms of opioid withdrawal.

The disclosure provides oral compositions including at least one active ingredient and a polymeric component, the oral compositions having a moisture content of at least about 10% by weight, based on total weight of the oral composition. The polymeric component includes a natural gum, a food grade polymer, or a combination thereof. The natural gum may be a non-galactomannan polysaccharide; a galactomannan polysaccharide selected from fenugreek gum, tara gum, locust bean gum, cassia gum, and combinations thereof; or a combination of guar gum and a second natural gum. The food grade polymer may be selected from proteins, synthetic polymers, non-cellulosic polysaccharides which are not natural gums, and combinations thereof.