The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.

Herbo-mineral formulation for prevention, treatment and management of Diabetes and method of preparing the same are disclosed herein. The disclosed herbo-mineral formulation includes herb and mineral elements which facilitate in treating Diabetes and Diabetes associated complications. Further the disclosed formulation has been observed to exhibit hypoglycemic, hypolipidemic, and pancreatic cell regenerative properties.

A preparation method of Gynostemma Pentaphyllus leaves extracts with increased amount of small molecular effective saponin and decreased benzopyrene includes the steps of drying fresh Gynostemma Pentaphyllus leaves after heating, treating the dried Gynostemma Pentaphyllus leaves with steam, adding water of 1 to 100-fold volume to the above Gynostemma Pentaphyllus leaves and then preparing a hot water extract by carrying out a hot water extraction at 100-180 V, 0.5-10 atm for 1-120 hours, adding C.sub.1-C.sub.4 lower alcohol of 1 to 100-fold volume to the residual remained after the hot water extraction and then preparing an alcohol extract of the residual from the hot water extract by carrying out an alcohol extraction at 50-100 C. for 1-4 hours, and mixing the hot water extract and the alcohol extract, and then filtering and concentrating the mixture.

A preparation method of Gynostemma Pentaphyllus leaves extracts with increased amount of small molecular effective saponin and decreased benzopyrene includes the steps of drying fresh Gynostemma Pentaphyllus leaves after heating, treating the dried Gynostemma Pentaphyllus leaves with steam, adding water of 1 to 100-fold volume to the above Gynostemma Pentaphyllus leaves and then preparing a hot water extract by carrying out a hot water extraction at 100-180 V, 0.5-10 atm for 1-120 hours, adding C.sub.1-C.sub.4 lower alcohol of 1 to 100-fold volume to the residual remained after the hot water extraction and then preparing an alcohol extract of the residual from the hot water extract by carrying out an alcohol extraction at 50-100 C. for 1-4 hours, and mixing the hot water extract and the alcohol extract, and then filtering and concentrating the mixture.

In an embodiment, a nutritional supplement composition is provided. The nutritional supplement composition is provided including a Houttuynia cordata extract of the Houttuynia cordata strain, maitake extract of the Grifola frondosa strain of mushrooms and Gynostemma extract of the leaf of the Gynostemma pentaphyllum strain. The nutritional supplement is in the form of a compound known as PERCYTE

In an embodiment, a nutritional supplement composition is provided. The nutritional supplement composition is provided including a Houttuynia cordata extract of the Houttuynia cordata strain, maitake extract of the Grifola frondosa strain of mushrooms and Gynostemma extract of the leaf of the Gynostemma pentaphyllum strain. The nutritional supplement is in the form of a compound known as PERCYTE

In an embodiment, a nutritional supplement composition is provided. The nutritional supplement composition is provided including a Houttuynia cordata extract of the Houttuynia cordata strain, maitake extract of the Grifola frondosa strain of mushrooms and Gynostemma extract of the leaf of the Gynostemma pentaphyllum strain. The nutritional supplement is in the form of a compound known as PERCYTE

The present disclosure relates to a method for preparing a Gynostemma pentaphyllum leaf extract, a Gynostemma pentaphyllum leaf extract prepared by the method, and a composition for improving exercise performance capacity containing the same as an active ingredient.

The Gynostemma pentaphyllum leaf extract according to the present disclosure exhibits superior effect of improving exercise performance capacity and enhancing muscle strength, endurance and physical strength. In addition, the Gynostemma pentaphyllum leaf extract according to the present disclosure has the efficacy of increasing AMPK activity, facilitating beta oxidation and facilitating glucose uptake and, thus, has superior effect of reducing body weight and body fat and preventing, alleviating or treating diabetes.

Because the composition of the present disclosure is derived from a natural product, it can be used usefully and safely for drugs, foods, etc. without side effects.

The present disclosure relates to a method for preparing a Gynostemma pentaphyllum leaf extract, a Gynostemma pentaphyllum leaf extract prepared by the method, and a composition for improving exercise performance capacity containing the same as an active ingredient.

The Gynostemma pentaphyllum leaf extract according to the present disclosure exhibits superior effect of improving exercise performance capacity and enhancing muscle strength, endurance and physical strength. In addition, the Gynostemma pentaphyllum leaf extract according to the present disclosure has the efficacy of increasing AMPK activity, facilitating beta oxidation and facilitating glucose uptake and, thus, has superior effect of reducing body weight and body fat and preventing, alleviating or treating diabetes.

Because the composition of the present disclosure is derived from a natural product, it can be used usefully and safely for drugs, foods, etc. without side effects.

The present disclosure relates to a composition for antiobesity, which contains a Gynostemma pentaphyllum tea or a Gynostemma pentaphyllum tea extract as an active ingredient.

The composition of the present disclosure, which contains a Gynostemma pentaphyllum tea or a Gynostemma pentaphyllum tea extract as an active ingredient, is effective for preventing, alleviating or treating diabetes, obesity, muscle loss, etc. since it exhibits the efficacy of increasing AMPK activity, promoting beta oxidation, promoting glucose uptake, etc.

In addition, since the composition of the present disclosure is derived from a natural product, it can be safely used as a drug, food, etc. without side effects.