The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-β-D-glucopyranoside, quercitrin, matairesinol-4′-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.

A betel leaf extracts composition having bactericidal, antiviral, and neutralization of virus SARS-CoV-2 properties by oral. The bactericidal, antiviral, and SARS-CoV-2 virus-neutralizing efficacy of betel leaf extract/essential oil was increased by the combination with the one or two or more active plant extracts/essential oils ingredients, 4-allylpyrocatechol (APC) ingredient, a mixture of ginger-honey, and a mixture of lemon-kumquat-cinnamon by predefined order and predetermined percentage by weight of each ingredient into an oral cavity delivery agent including a range of gum, confectionery/candy, lozenge, tablet, edible film, oral film, oral solution and oral spray solution.

A betel leaf extracts composition having bactericidal, antiviral, and neutralization of virus SARS-CoV-2 properties by oral. The bactericidal, antiviral, and SARS-CoV-2 virus-neutralizing efficacy of betel leaf extract/essential oil was increased by the combination with the one or two or more active plant extracts/essential oils ingredients, 4-allylpyrocatechol (APC) ingredient, a mixture of ginger-honey, and a mixture of lemon-kumquat-cinnamon by predefined order and predetermined percentage by weight of each ingredient into an oral cavity delivery agent including a range of gum, confectionery/candy, lozenge, tablet, edible film, oral film, oral solution and oral spray solution.

The present invention relates to a composition for the prevention or treatment of respiratory diseases containing an Agastacherugosa and licorice extract as an active ingredient, and more specifically, the present invention relates to a composition for the prevention or treatment of respiratory diseases caused by fine dust containing an extract, in which Agastacherugosa and licorice are mixed at a weight ratio of 1:1 to 6:1, as an active ingredient.

The Agastacherugosa and licorice extract of the present invention has the efficacies of reducing cough through inhibition of TRPV1 activity, reducing lung inflammation through inhibition of CXCR1 and CXCR2 activities and GR-1+CD11b+ cell ratio reduction, and suppressing sputum production through inhibition of MUC5AC activity. In particular, since it is confirmed that the efficacy of the Agastacherugosa and licorice complex mixture is maximized at a specific mixing ratio, it can be widely utilized as a composition for the prevention or treatment of respiratory diseases caused by fine dust.

The present invention relates to a composition for the prevention or treatment of respiratory diseases containing an Agastacherugosa and licorice extract as an active ingredient, and more specifically, the present invention relates to a composition for the prevention or treatment of respiratory diseases caused by fine dust containing an extract, in which Agastacherugosa and licorice are mixed at a weight ratio of 1:1 to 6:1, as an active ingredient.

The Agastacherugosa and licorice extract of the present invention has the efficacies of reducing cough through inhibition of TRPV1 activity, reducing lung inflammation through inhibition of CXCR1 and CXCR2 activities and GR-1+CD11b+ cell ratio reduction, and suppressing sputum production through inhibition of MUC5AC activity. In particular, since it is confirmed that the efficacy of the Agastacherugosa and licorice complex mixture is maximized at a specific mixing ratio, it can be widely utilized as a composition for the prevention or treatment of respiratory diseases caused by fine dust.

The present invention provides a composition, for preventing or treating an inflammatory disease, comprising, as an active ingredient, a self-hydrolysis extract using a hydrolase in a plant cell from one or more plants selected from Pulsatilla koreana, Pulsatilla chinensis, Pulsatilla cernua, Anemone raddeana, Aralia elata, Akebia quinata, Lonicera species, Adonis amurensis, Hedera helix, Hedera colchica and Patrinia scabiosifolia, and/or additionally an angiogenesis inhibitor.

The present invention provides a composition, for preventing or treating an inflammatory disease, comprising, as an active ingredient, a self-hydrolysis extract using a hydrolase in a plant cell from one or more plants selected from Pulsatilla koreana, Pulsatilla chinensis, Pulsatilla cernua, Anemone raddeana, Aralia elata, Akebia quinata, Lonicera species, Adonis amurensis, Hedera helix, Hedera colchica and Patrinia scabiosifolia, and/or additionally an angiogenesis inhibitor.

The present invention relates to a composition, comprising a vinegar pickled egg as an active ingredient, for prevention, alleviation, or treatment of diabetic foot ulcer. More specifically, a vinegar pickled egg fermentate obtained by adding and fermentating egg white of pullet eggs with medicinal herb vinegar does not irritate the skin and is effective for alleviating diabetic foot ulcer, thus being able to find advantageous applications as a therapeutic agent for diabetic foot ulcer, an anti-diabetic foot ulcer skin preparation for external use, or a substance for a health functional food for prevention or alleviation of diabetic foot ulcer.

The present invention relates to a composition, comprising a vinegar pickled egg as an active ingredient, for prevention, alleviation, or treatment of diabetic foot ulcer. More specifically, a vinegar pickled egg fermentate obtained by adding and fermentating egg white of pullet eggs with medicinal herb vinegar does not irritate the skin and is effective for alleviating diabetic foot ulcer, thus being able to find advantageous applications as a therapeutic agent for diabetic foot ulcer, an anti-diabetic foot ulcer skin preparation for external use, or a substance for a health functional food for prevention or alleviation of diabetic foot ulcer.

A composition for strengthening skin barrier or improving skin barrier function is able to improve objective indicators related to the protection of skin barrier, the strengthening of skin barrier, and/or the improvement of skin barrier function. The composition exhibits the effects of increasing the amount of ceramides, dihydroceramides and sphingoid bases, increasing the activities of enzymes that are involved in the synthesis thereof, and decreasing the activities of enzymes that are involved in the degradation thereof. In addition, the composition is able to restore skin barrier function by reducing TSLP, IL-4, and IL-13 which are closely associated with skin barrier damage, and thus interrupting a vicious circle in which the lipids and proteins contributing to skin barrier decrease.