A61K36/486

Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
09622964 · 2017-04-18 · ·

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-Ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
09622964 · 2017-04-18 · ·

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-Ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
09622964 · 2017-04-18 · ·

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-Ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS AS A THERAPEUTIC AGENT
20170071997 · 2017-03-16 ·

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

Medication and application for treatment of hypertension based on Anion and Traditional Chinese medicine
20170007641 · 2017-01-12 ·

A medicament for treatment of hypertension based on anion and traditional Chinese medicine, containing active ingredients by percentage weight, which are: 930% of Scutellaria baicalensis, 39% of Radix Bupleuri, 312% of Uncaria tomentosa (cat's claw), 39% of Ginseng, 1525% of Cynanchum mooreanum Hemsl., 39% of Cordyceps sinensis (Berk.) Sacc., 1015% of Flastem Milkvetch Seed, 915% of Dermatocarpon miniatum(L.)Mann. [Lichen miniatius L.], 1015% of Millettia dielsiana, 1015% of stem or root of Dalbergia hancei Benth. (Leguminosae), 14% of anion powder and 14% of far-infrared nano powder. Through the use of far infrared nano powder and anion powder with low cost and easily obtainable traditional Chinese medicine, the traditional Chinese medicine is further strengthened with increased efficacy while the far infrared and anion promotes blood circulation and cell repair, which in turn further increases the efficacy and treatment result.

Medication and application for treatment of hypertension based on Anion and Traditional Chinese medicine
20170007641 · 2017-01-12 ·

A medicament for treatment of hypertension based on anion and traditional Chinese medicine, containing active ingredients by percentage weight, which are: 930% of Scutellaria baicalensis, 39% of Radix Bupleuri, 312% of Uncaria tomentosa (cat's claw), 39% of Ginseng, 1525% of Cynanchum mooreanum Hemsl., 39% of Cordyceps sinensis (Berk.) Sacc., 1015% of Flastem Milkvetch Seed, 915% of Dermatocarpon miniatum(L.)Mann. [Lichen miniatius L.], 1015% of Millettia dielsiana, 1015% of stem or root of Dalbergia hancei Benth. (Leguminosae), 14% of anion powder and 14% of far-infrared nano powder. Through the use of far infrared nano powder and anion powder with low cost and easily obtainable traditional Chinese medicine, the traditional Chinese medicine is further strengthened with increased efficacy while the far infrared and anion promotes blood circulation and cell repair, which in turn further increases the efficacy and treatment result.

Medication and application for treatment of hypertension based on Anion and Traditional Chinese medicine
20170007641 · 2017-01-12 ·

A medicament for treatment of hypertension based on anion and traditional Chinese medicine, containing active ingredients by percentage weight, which are: 930% of Scutellaria baicalensis, 39% of Radix Bupleuri, 312% of Uncaria tomentosa (cat's claw), 39% of Ginseng, 1525% of Cynanchum mooreanum Hemsl., 39% of Cordyceps sinensis (Berk.) Sacc., 1015% of Flastem Milkvetch Seed, 915% of Dermatocarpon miniatum(L.)Mann. [Lichen miniatius L.], 1015% of Millettia dielsiana, 1015% of stem or root of Dalbergia hancei Benth. (Leguminosae), 14% of anion powder and 14% of far-infrared nano powder. Through the use of far infrared nano powder and anion powder with low cost and easily obtainable traditional Chinese medicine, the traditional Chinese medicine is further strengthened with increased efficacy while the far infrared and anion promotes blood circulation and cell repair, which in turn further increases the efficacy and treatment result.

TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING CARDIOVASCULAR AND KIDNEY DISEASES AND METHOD FOR PREPARING SAME
20250345381 · 2025-11-13 ·

Provided are a traditional Chinese medicine composition for treating cardiorenal syndrome and cardiac failure and a method for preparing same. The traditional Chinese medicine composition is prepared from the following raw materials: 3 to 20 parts of Cinnamomi ramulus, 3 to 25 parts of Atractylodis macrocephalae rhizoma, 3 to 25 parts of Jujubae fructus, 6 to 45 parts of Astragali radix, 2 to 20 parts of Panacis majoris rhizoma, 3 to 30 parts of Paeoniae rubra radix, 6 to 25 parts of Spatholobi caulis, 6 to 25 parts of Ginkgo folium, 6 to 35 parts of Poria, 3 to 20 parts of Zingiberis rhizoma recens, 2 to 25 parts of Citri fructus, 2 to 15 parts of Nigellae semen, 2 to 20 parts of Inulae flos, and 3 to 25 parts of Alismatis rhizoma.

TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING CARDIOVASCULAR AND KIDNEY DISEASES AND METHOD FOR PREPARING SAME
20250345381 · 2025-11-13 ·

Provided are a traditional Chinese medicine composition for treating cardiorenal syndrome and cardiac failure and a method for preparing same. The traditional Chinese medicine composition is prepared from the following raw materials: 3 to 20 parts of Cinnamomi ramulus, 3 to 25 parts of Atractylodis macrocephalae rhizoma, 3 to 25 parts of Jujubae fructus, 6 to 45 parts of Astragali radix, 2 to 20 parts of Panacis majoris rhizoma, 3 to 30 parts of Paeoniae rubra radix, 6 to 25 parts of Spatholobi caulis, 6 to 25 parts of Ginkgo folium, 6 to 35 parts of Poria, 3 to 20 parts of Zingiberis rhizoma recens, 2 to 25 parts of Citri fructus, 2 to 15 parts of Nigellae semen, 2 to 20 parts of Inulae flos, and 3 to 25 parts of Alismatis rhizoma.

COMPOSITION FOR PREVENTING, IMPROVING, OR MITIGATING KIDNEY-DEFICIENCY-ASSOCIATED SYMPTOMS OR CONDITIONS OF SKIN, HAIR, AND NAILS

A composition includes the following active components: component (1): at least one selected from the group consisting of Ligustrum fruit, yerbadetajo herb, Lilium bulb, Polygonatum Rhizome, Lycium fruit, Sesamum indicum, and black soybean; component (2): at least one selected from the group consisting of Suberect spatholobus stem, Longan aril, wild turmeric, zedoary root, Luffa vegetable sponge, Sparganium rhizome, safflower, Artemisia anomala, common fenugreek seed, Dipsacus japonicus root, Drynaria herb, sea horse, Cynomorium herb, and Astragalus Seed; component (3): at least one selected from the group consisting of tea leaf, plantago seed, plantago herb, coix seed, small red-bean, corn silk, Lophatherum herb, Benincasa seed, mallow seed, knotgrass, and Lygodium spore; and component (4): at least one selected from the group consisting of Dioscorea japonica Thunberg, Eleutherococcus senticosus Rhizome, honey, oriental bush cherry, ginger root, ripe tangerine peel, unripe tangerine peel, immature orange, malt starch syrup, jujube fruit, and non-glutinous rice.