The present invention provides compositions of bakuchiol (UP246) having low levels of impurities, particularly furanocoumarin impurities. The present invention further provides improved methods for the isolation, purification and analysis of compositions of bakuchiol. Finally, the present invention provides methods for using the purified bakuchiol compositions and formulations thereof for the prevention and treatment of various diseases and conditions mediated by cyclooxygenase (COX), lipoxygenase (LOX), minor inflammatory conditions and various microbial infections. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.

The present invention provides compositions of bakuchiol (UP246) having low levels of impurities, particularly furanocoumarin impurities. The present invention further provides improved methods for the isolation, purification and analysis of compositions of bakuchiol. Finally, the present invention provides methods for using the purified bakuchiol compositions and formulations thereof for the prevention and treatment of various diseases and conditions mediated by cyclooxygenase (COX), lipoxygenase (LOX), minor inflammatory conditions and various microbial infections. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.

A first embodiment of a composition for treating vitiligo includes Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, and Psoralea corylifolia black seed powder. A second embodiment of a composition for treating vitiligo can include Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, Berberries (or Berberis) vulgaris root powder, red clay (with trace copper), and Ptychotis verticillata root powder. Topical administration of the first composition followed by UV radiation exposure can facilitate inducing melanogenesis as well as generating ROS. Topical administration of the second composition following the UV radiation exposure can scavenge the ROS generated by the first composition.

A first embodiment of a composition for treating vitiligo includes Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, and Psoralea corylifolia black seed powder. A second embodiment of a composition for treating vitiligo can include Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, Berberries (or Berberis) vulgaris root powder, red clay (with trace copper), and Ptychotis verticillata root powder. Topical administration of the first composition followed by UV radiation exposure can facilitate inducing melanogenesis as well as generating ROS. Topical administration of the second composition following the UV radiation exposure can scavenge the ROS generated by the first composition.

A first embodiment of a composition for treating vitiligo includes Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, and Psoralea corylifolia black seed powder. A second embodiment of a composition for treating vitiligo can include Cassia tora powder, Saussurea lappa root powder, Punica granatum L. (pomegranate) peels powder, Berberries (or Berberis) vulgaris root powder, red clay (with trace copper), and Ptychotis verticillata root powder. Topical administration of the first composition followed by UV radiation exposure can facilitate inducing melanogenesis as well as generating ROS. Topical administration of the second composition following the UV radiation exposure can scavenge the ROS generated by the first composition.

A pharmaceutical composition that is effective in relieving pain from joint and muscle strain is disclosed herein. The pharmaceutical composition comprises a combination of Pecan kernels; Eucommia ulmoides barks; and Psoralea corylifolia seeds as it active ingredients.

A pharmaceutical composition that is effective in relieving pain from joint and muscle strain is disclosed herein. The pharmaceutical composition comprises a combination of Pecan kernels; Eucommia ulmoides barks; and Psoralea corylifolia seeds as it active ingredients.

A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol(TM), which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.

A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol(TM), which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.

A composition for the treatment of acne includes hydrolyzed Psoralea Corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In a specific implementation, the composition is a water-based acne gel. In a specific implementation, a composition includes Bakutrol, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.