A Fructus Forsythiae and Radix Astragali compound preparation, and a preparation method therefor and a use thereof is provided. Traditional Chinese medicine formulation components consist of the following raw materials or raw material extracts in parts by mass: 9-11 parts of Flos Lonicerae, 9-11 parts of Fructus Forsythiae, 9-11 parts of Radix Scutellariae, 9-11 parts of Herba Artemisiae Annuae, 9-11 parts of Radix Astragali, 9-11 parts of stir-fried Rhizoma Atractylodis Macrocephalae, 9-11 parts of Herba Pogostemonis, 5-7 parts of Radix Saposhnikoviae, 9-11 parts of Radix Ophiopogonis, and 5-7 parts of Radix Glycyrrhizae. The components can be made into an oral liquid, a granule, a dissolved medicine, or a tablet. Further disclosed is a use of the Fructus Forsythiae and Radix Astragali compound preparation in preparation of medicines for preventing and/or treating a viral influenza disease.

To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1 released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.

To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1 released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.

Disclosed are a preparation method for a Forsythia suspensa leaf extract and a use of the extract for increasing the abundance of AKK in intestinal tracts, which relate to the technical field of medicine. The preparation method for the Forsythia suspensa leaf extract includes: taking Forsythia suspensa leaves, adding a solvent at 90? C. or more for 10 to 40 minutes, filtering and then adding an extractant for extraction to obtain a first product; filtering the first product, taking a supernatant, adsorbing, eluting, and concentrating under reduced pressure to obtain an extract, and freeze-drying to obtain a second product; and dissolving the second product in water, carrying out chromatography, then eluting, collecting an eluate, concentrating under reduced pressure, and freeze-drying into a powder form to obtain the Forsythia suspensa leaf extract.

Disclosed are a preparation method for a Forsythia suspensa leaf extract and a use of the extract for increasing the abundance of AKK in intestinal tracts, which relate to the technical field of medicine. The preparation method for the Forsythia suspensa leaf extract includes: taking Forsythia suspensa leaves, adding a solvent at 90? C. or more for 10 to 40 minutes, filtering and then adding an extractant for extraction to obtain a first product; filtering the first product, taking a supernatant, adsorbing, eluting, and concentrating under reduced pressure to obtain an extract, and freeze-drying to obtain a second product; and dissolving the second product in water, carrying out chromatography, then eluting, collecting an eluate, concentrating under reduced pressure, and freeze-drying into a powder form to obtain the Forsythia suspensa leaf extract.

Provided is a traditional Chinese medicine composition for treating urticaria, eczema, and allergic constitution. The composition is traditional Chinese medicine formula I, II, or an adjusted combination formula thereof. The traditional Chinese medicine formula I includes: Scutellariae Radix, Coptidis Rhizoma, Forsythiae fructus, Perillae folium, Magnoliae officinalis cortex, Atractylodis macrocephalae rhizoma, Radix Angelicae, Paeoniae alba radix, Cassiae semen, Cortex Phellodendri, Stemonae radix, Artemisiae annuae herba, Anemarrhenae rhizoma, Trichosanthis radix, Glycyrrhizae radix et rhizoma, Herba Menthae, Rhizoma Dryopteris Crassirhizomae, Salviae miltiorrhizae radix et rhizoma, Violae herba, and extract of Isatidis folium. The traditional Chinese medicine formula II includes Glycyrrhizae radix et rhizoma, Herba Menthae, Chuanxiong rhizoma, Gentianae radix et rhizoma, Moslae herba, Taraxaci herba, Rhei radix et rhizoma, Senecionis scandentis herba, Zingiberis rhizoma recens, Flos Lonicerae, Chebulae fructus, Belamcandae rhizoma, Pulsatillae radix, Moutan cortex, Magnoliae flos, Corni fructus, Herba Agastachis, Picrorhizae rhizoma, Dictamni cortex, Schizonepetae herba, and Flos Dendranthema morifolium (extract).

Provided is a traditional Chinese medicine composition for treating urticaria, eczema, and allergic constitution. The composition is traditional Chinese medicine formula I, II, or an adjusted combination formula thereof. The traditional Chinese medicine formula I includes: Scutellariae Radix, Coptidis Rhizoma, Forsythiae fructus, Perillae folium, Magnoliae officinalis cortex, Atractylodis macrocephalae rhizoma, Radix Angelicae, Paeoniae alba radix, Cassiae semen, Cortex Phellodendri, Stemonae radix, Artemisiae annuae herba, Anemarrhenae rhizoma, Trichosanthis radix, Glycyrrhizae radix et rhizoma, Herba Menthae, Rhizoma Dryopteris Crassirhizomae, Salviae miltiorrhizae radix et rhizoma, Violae herba, and extract of Isatidis folium. The traditional Chinese medicine formula II includes Glycyrrhizae radix et rhizoma, Herba Menthae, Chuanxiong rhizoma, Gentianae radix et rhizoma, Moslae herba, Taraxaci herba, Rhei radix et rhizoma, Senecionis scandentis herba, Zingiberis rhizoma recens, Flos Lonicerae, Chebulae fructus, Belamcandae rhizoma, Pulsatillae radix, Moutan cortex, Magnoliae flos, Corni fructus, Herba Agastachis, Picrorhizae rhizoma, Dictamni cortex, Schizonepetae herba, and Flos Dendranthema morifolium (extract).

The present disclosure relates to a method for manufacturing a device for herbal medicine in which the airborne release of medicinal ingredients can be controlled, which comprises: separating two or more medicinal herbal ingredients prescribed or prepared according to pharmacological effects on the basis of the weight ratio of each medicinal ingredient to total weight of the medicinal ingredients; grinding the medicinal ingredients separated on the basis of weight ratio, wherein fine particles are ground to different sizes according to the setting of release duration; preparing herbal medicine by mixing the ground medicinal ingredients together, and then mixing the ingredients with a binding agent; and adhering the herbal medicine to a base sheet. The device for herbal medicine manufactured according to the method allows for persistent permeation of medical ingredients through mucous membrane with different release rate for each medicinal ingredient, and thus, the efficacy of the medicinal ingredient layer and the effect of treating disease can be maximized.

The present disclosure relates to a method for manufacturing a device for herbal medicine in which the airborne release of medicinal ingredients can be controlled, which comprises: separating two or more medicinal herbal ingredients prescribed or prepared according to pharmacological effects on the basis of the weight ratio of each medicinal ingredient to total weight of the medicinal ingredients; grinding the medicinal ingredients separated on the basis of weight ratio, wherein fine particles are ground to different sizes according to the setting of release duration; preparing herbal medicine by mixing the ground medicinal ingredients together, and then mixing the ingredients with a binding agent; and adhering the herbal medicine to a base sheet. The device for herbal medicine manufactured according to the method allows for persistent permeation of medical ingredients through mucous membrane with different release rate for each medicinal ingredient, and thus, the efficacy of the medicinal ingredient layer and the effect of treating disease can be maximized.

The present disclosure relates to a method for manufacturing a device for herbal medicine in which the airborne release of medicinal ingredients can be controlled, which comprises: separating two or more medicinal herbal ingredients prescribed or prepared according to pharmacological effects on the basis of the weight ratio of each medicinal ingredient to total weight of the medicinal ingredients; grinding the medicinal ingredients separated on the basis of weight ratio, wherein fine particles are ground to different sizes according to the setting of release duration; preparing herbal medicine by mixing the ground medicinal ingredients together, and then mixing the ingredients with a binding agent; and adhering the herbal medicine to a base sheet. The device for herbal medicine manufactured according to the method allows for persistent permeation of medical ingredients through mucous membrane with different release rate for each medicinal ingredient, and thus, the efficacy of the medicinal ingredient layer and the effect of treating disease can be maximized.