A method of designing a gas turbine engine includes configuring a speed reduction device for driving a fan and configuring a lubrication system for lubricating components across a rotation gap. The lubrication system includes a lubricant input. A stationary first bearing receives lubricant from the lubricant input and has a first race in which lubricant flows. A second bearing for rotation is within the first bearing. The second bearing has a first opening in registration with the first race such that lubricant may flow from the first race through the first opening into a first conduit. The first bearing is configured to also include a second race into which lubricant flows. The second bearing has a second opening in registration with the second race such that lubricant may flow from the second race through the second opening into a second conduit. The first and second conduits deliver lubricant to distinct locations.

A method of designing a gas turbine engine includes configuring a speed reduction device for driving a fan and configuring a lubrication system for lubricating components across a rotation gap. The lubrication system includes a lubricant input. A stationary first bearing receives lubricant from the lubricant input and has a first race in which lubricant flows. A second bearing for rotation is within the first bearing. The second bearing has a first opening in registration with the first race such that lubricant may flow from the first race through the first opening into a first conduit. The first bearing is configured to also include a second race into which lubricant flows. The second bearing has a second opening in registration with the second race such that lubricant may flow from the second race through the second opening into a second conduit. The first and second conduits deliver lubricant to distinct locations.

Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor. When so configured, such controller can transmit a value representing a magnitude of the measured pressure variation to a display associated with the extracorporeal blood circuit.

Aspects and techniques of the present disclosure relate to a bleed valve system for bleeding fluid of a first, lower, specific gravity from a fluid of a second, higher, specific gravity, in a fluid system. The techniques can be used to provide a bleed valve system, for a pressurized fluid system, that is not sensitive to rotational orientation around a mounting axis.

A method, apparatus, and system for obtaining a solution from a solid product are disclosed. A solid product is housed in a dispenser. A liquid is introduced into the housing of the dispenser to interact with the solid product to form a solution. To control the concentration of the formed solution, the turbulence of the liquid introduced to the dispenser is controlled and adjusted either manually or on a real time basis to account for varying characteristics of either or both of the solid product and the liquid. The dispenser will adjust the turbulence based on the characteristics to maintain a formed solution within an acceptable range of concentration. The concentrated solution can then be discharged from the dispenser to an end use application.

Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

A hemodialysis apparatus comprising diaphragm pumps for the movement of both dialysate and blood, and under the control of a controller, is capable of detecting blood flow conditions that give rise to an alarm and implement procedures to adjust, pause, or halt the pumping of dialysate and/or blood. The controller can direct the application of a time-varying pressure to fluid in the control chamber of a blood pump, and monitor the resulting pressure waveform during a fill stroke of the blood pump. A deviation of the measured pressure variation from an expected value can give rise to an alert to a user and to the initiation of an adjustment, pause, or cessation of the dialysate pump's activity.

The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.

In an embodiment of the present disclosure, a gas turbine engine includes a fan, a first compressor stage and a second compressor stage, a first turbine stage and a second turbine stage, and wherein said first turbine stage drives said second compressor stage as a high spool, and wherein said second turbine stage drives said first compressor stage as part of a low spool, and a gear train driving said fan with said low spool, and such that said fan and said first compressor stage rotate in the same direction, and wherein said high spool operates at higher pressures than said low spool.