Provided are compositions and methods comprising a sanshool for the treatment of obesity as part of a controlled diet regime in an individual. Also provided are compositions and methods comprising a sanshool for treatment of a smoking or vaping addiction. Suitably the compositions are applied topically to the lips of the individual in response to a habitual urge to consume food, smoke or vape as required.

Provided are compositions and methods comprising a sanshool for the treatment of obesity as part of a controlled diet regime in an individual. Also provided are compositions and methods comprising a sanshool for treatment of a smoking or vaping addiction. Suitably the compositions are applied topically to the lips of the individual in response to a habitual urge to consume food, smoke or vape as required.

A microbial Chinese herbal medicine feed having effects of detoxication, muttony odor removal, flavor enhancement and mutton quality improvement, comprising 190-1920 parts of feed substrate, 39-238 parts of additives, 1-65 parts of Chinese herbal medicine components, and 100-550 parts of forage powder; the Chinese herbal medicine components comprise fructus aurantii, dried tangerine peel, Amomum villosum and so on. The formula of the invention can obviously decrease the synthesis of short-chain fatty acids and C18 fatty acids in sheep, inhibit and block the further combination of C6, C8 and C10 into stable complexes or associations to the greatest extent and effectively improve the quality of the mutton, particularly effective in removing odor of the mutton.

A microbial Chinese herbal medicine feed having effects of detoxication, muttony odor removal, flavor enhancement and mutton quality improvement, comprising 190-1920 parts of feed substrate, 39-238 parts of additives, 1-65 parts of Chinese herbal medicine components, and 100-550 parts of forage powder; the Chinese herbal medicine components comprise fructus aurantii, dried tangerine peel, Amomum villosum and so on. The formula of the invention can obviously decrease the synthesis of short-chain fatty acids and C18 fatty acids in sheep, inhibit and block the further combination of C6, C8 and C10 into stable complexes or associations to the greatest extent and effectively improve the quality of the mutton, particularly effective in removing odor of the mutton.

A topical TCM composition and topical preparation for a cervical disease, and preparation methods thereof are provided. The topical TCM composition is prepared from the following components in parts by weight: Cortex Ailanthi; fried Ginkgo nut; Phellodendron amurense; Cnidium monnieri fruit; Radix Sophorae Flavescentis; Sichuan pepper; Cyrtomium fortunei; Indigo naturalis; Ligustrum lucidum; Halloysitum Rubrum; Radix rehmanniae praeparata; Houttuynia Cordata; charred Zingiberis Rhizoma Recens; Radix Boehmeriae; Rhizoma Atractylodis; Chinese smartweed; Herba Patriniae; Radix et Rhizoma Rhei; Solanum nigrum; Rhizoma Bletillae; Radix Notoginseng; Fructus Piperis Longi; and licorice root.

A topical TCM composition and topical preparation for a cervical disease, and preparation methods thereof are provided. The topical TCM composition is prepared from the following components in parts by weight: Cortex Ailanthi; fried Ginkgo nut; Phellodendron amurense; Cnidium monnieri fruit; Radix Sophorae Flavescentis; Sichuan pepper; Cyrtomium fortunei; Indigo naturalis; Ligustrum lucidum; Halloysitum Rubrum; Radix rehmanniae praeparata; Houttuynia Cordata; charred Zingiberis Rhizoma Recens; Radix Boehmeriae; Rhizoma Atractylodis; Chinese smartweed; Herba Patriniae; Radix et Rhizoma Rhei; Solanum nigrum; Rhizoma Bletillae; Radix Notoginseng; Fructus Piperis Longi; and licorice root.

A traditional Chinese herbal composition for treating allergic conjunctivitis and/or allergic rhinitis is prepared from the following raw material herbals in a weight ratio: 3-7 parts of szechuan pepper, 7-13 parts of szechuan lovage rhizome, 7-13 parts of belvedere fruit, 10-15 parts of common anemarrhena rhizome, 7-13 parts of divaricate saposhnikovia root, 4-8 parts of periostracum cicadae, and 7-13 parts of great burdock achene. The traditional Chinese herbal composition has the effects of dispelling wind, clearing heat and relieving itching, and has significant effects on treating allergic conjunctivitis and allergic rhinitis.

A traditional Chinese herbal composition for treating allergic conjunctivitis and/or allergic rhinitis is prepared from the following raw material herbals in a weight ratio: 3-7 parts of szechuan pepper, 7-13 parts of szechuan lovage rhizome, 7-13 parts of belvedere fruit, 10-15 parts of common anemarrhena rhizome, 7-13 parts of divaricate saposhnikovia root, 4-8 parts of periostracum cicadae, and 7-13 parts of great burdock achene. The traditional Chinese herbal composition has the effects of dispelling wind, clearing heat and relieving itching, and has significant effects on treating allergic conjunctivitis and allergic rhinitis.

A traditional Chinese herbal composition for treating allergic conjunctivitis and/or allergic rhinitis is prepared from the following raw material herbals in a weight ratio: 3-7 parts of szechuan pepper, 7-13 parts of szechuan lovage rhizome, 7-13 parts of belvedere fruit, 10-15 parts of common anemarrhena rhizome, 7-13 parts of divaricate saposhnikovia root, 4-8 parts of periostracum cicadae, and 7-13 parts of great burdock achene. The traditional Chinese herbal composition has the effects of dispelling wind, clearing heat and relieving itching, and has significant effects on treating allergic conjunctivitis and allergic rhinitis.

Novel HIF inhibitors having low cytotoxicity and suitable for ophthalmologic treatment and agents for the treatment or prevention of ischemic diseases, glaucoma, optic nerve diseases, retinal degenerative diseases, retinal degenerative diseases, angiogenic retinal diseases, cancer, neurodegenerative or autoimmune diseases are provided.

The present invention is a therapeutic or prophylactic agent for ischemic disease, glaucoma, optic nerve disease, retinal degenerative disease, retinal degenerative disease, angiogenic retinal disease, cancer, neurodegenerative disease, or autoimmune disease, which comprises as an active ingredient one or more or an extract thereof selected from the group consisting of plants belonging to the genus Asian, plants belonging to the genus Swiss, plants belonging to the genus Grape, plants belonging to the genus Brassica, fish belonging to the genus Kivinago, and so on.