Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

A pressurization device for pressurizing an enclosure may include a container containing a pressurized fluid, a pin that is inserted into the container, an actuator, and a heating device operably coupled to the actuator. The actuator may initially hold the pin in a closed position and allow the pin to move to an open position, disengaging from the container when the actuator increases in temperature. The pressurized fluid may force the pin toward the open position to release the pressurized fluid from the container. The actuator may include a frangible hollow bulb configured to fracture at a pre-defined temperature. The pressurized fluid may be vented into the enclosure through at least one fluid passage in fluid communication between the enclosure and the container.

A pressurization device for pressurizing an enclosure may include a container containing a pressurized fluid, a pin that is inserted into the container, an actuator, and a heating device operably coupled to the actuator. The actuator may initially hold the pin in a closed position and allow the pin to move to an open position, disengaging from the container when the actuator increases in temperature. The pressurized fluid may force the pin toward the open position to release the pressurized fluid from the container. The actuator may include a frangible hollow bulb configured to fracture at a pre-defined temperature. The pressurized fluid may be vented into the enclosure through at least one fluid passage in fluid communication between the enclosure and the container.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

A thermal safety device includes a device body with an inlet duct and at least one outlet hole in communication with the atmosphere, a shut-off device mounted in the device body and movable between a closed position and an open position, and a retaining element that keeps the shut-off device in the closed position. The retaining element includes a casing containing a heat sensitive substance configured to expand upon reaching a first predetermined temperature and break the casing and allow the valve to open. A yielding support element provides support for and protects the casing until the temperature reached by the support element is higher than a second predetermined temperature which is higher than the first. The support element is configured to yield upon reaching the second predetermined temperature to place the shut-off device in the open position.

A safety valve includes: a valve element; a valve seat that has a gas release hole from which a gas is released and a protrusion that protrudes towards the valve element; and a meltable body that is made of a material capable of being melt at an abnormal high temperature. At a temperature other than the abnormal high temperature, the meltable body limits displacement of the valve element to thereby prevent inflow of the gas towards the gas release hole. At the abnormal high temperature, the meltable body is melt, thereby the valve element is displaced and the gas is released from the gas release hole.