A compartmentalized protective case houses a portable electronic device and personal care items that are organized and held securely therewithin. The compartmentalized protective case has a major compartment for receiving and housing an electronic device such as a smart phone, cellular phone, music player, or other digital media device. At least one cell compartment constructed within the case receives and houses personal care items removably integrated therein. Personal care items can include at least one interchangeable replacement cell containing beauty items, cosmetics, hygienic items, oral care products such as floss or breath strips, medications, vitamins, breathe fresheners and/or health care products. A second cell compartment is preferably provided as a removable pouch or may contain a restraining system for holding identification cards, currency, visa or bank cards, and/or keys.

Disclosed is a portable suitcase, comprising a case, a case lid, a box, and a cover plate. Side walls of the case and a bottom surface of the case enclose a first accommodation space, tops of the side walls enclose a first opening, and the first opening is connected to the first accommodation space. One of sides of the case lid is rotatably connected to the top of one of the side walls of the case. A top of the box forms a second opening, the box is rotatably connected to an inner side wall of the case. The cover plate includes opposing a first side and a second side, the first side is rotatably connected to the case lid, and both ends of the second side are slidably connected to tops of two opposing interior side walls of the box.