The present invention provides a lipid nanoparticle comprising a fentanyl hapten, and a T helper peptide and/or an adjuvant, wherein the fentanyl hapten is conjugated to the outer surface of the lipid nanoparticle, and wherein the T helper peptide and/or the adjuvant is/are encapsulated within the lipid nanoparticle. The invention further provides a pharmaceutical composition comprising the lipid nanoparticle and uses thereof for inducing an immune response against fentanyl and the prevention or treatment of a fentanyl abuse disorder or a fentanyl addiction or a fentanyl overdose in a subject. Further provided herein is a method for preparing the lipid nanoparticle of the invention.

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.

The present invention encompasses an antithrombotic nanoparticle and use thereof.

The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.

Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated componentMAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

The present invention provides a therapeutic agent for refractory viral infections, etc., which is capable of reducing or eliminating cccDNA from hepatocytes. The therapeutic agent for refractory viral infections according to the present invention is characterized by comprising a complex encapsulating poly-I or a poly-I analog and poly-C or a poly-C analog within a drug carrier useful for drug delivery into cells, wherein the surface of the carrier is conjugated with a molecule imparting the ability to accumulate in hepatocytes.

The present invention relates to compositions and methods for effective delivery of an agent to a stem cell using a delivery vehicle comprising a stem cell targeting domain.

A preparation method of lipid bubbles by utilizing the principle of natural adsorption and assembly of amphiphilic lipid molecules on a gas-liquid interface comprises the steps of mixing gas-dissolved water containing free bubbles with lipid materials, and then the lipid materials are dispersed in the free gas nanobubble aqueous solution, and, in the presence of free bubbles, adsorbed and assembled on the gas-liquid interfaces so as to form lipid bubbles. The method is different from the traditional ultrasound cavitation, the mechanical force action, the novel ink jet printing method, the microchannel method and other methods for preparing bubbles.

The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.