A particulate, modified release barrier coated drug-cation exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. Methods of making and products containing this coated complex are described.

The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject.

Compounds of formula I and II:

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or a pharmaceutically acceptable salt thereof, and their compositions including polymer encapsulated micro/nano particle compositions are provided, wherein: R.sup.1 is —CH.sub.2—, a C.sub.2-6 straight or branched chain alkylene, alkenylene or alkynylene group or a short chain polyethylene glycol group having 2-6 monomers, or a combination thereof; R.sup.2 is hydrogen or —(C═O)R.sup.3 wherein R.sup.3 is a C2-6 straight or branched chain alkylene, alkenylene or alkynylene group or a short chain polyethylene glycol group having 2-6 monomers, or a combination thereof; and R.sup.4 is a pharmaceutically acceptable polymeric moiety comprising a pharmaceutically acceptable polymer chain such that R.sup.1 is linked to the polymer chain through an ester, carbonate or carbamate bond including the oxygen atom linking R.sup.1 and R.sup.4.

The compositions are useful for treatment of multiple myeloma, mantle cell lymphoma, and transfusion-dependent anemia due to myelodysplastic syndromes.

Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent.

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

The present disclosure provides compositions for inducing immune tolerance and methods to modify antigen to treat allergy and autoimmune disease. Disclosed are compositions, and related methods, comprising APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to antigen. In some embodiments, the composition is in a skin patch.

The present invention provides homing peptides that localize in central nervous system tissue characterized by neuroinflammation and methods of using the same.

Bacteriophage covalently attached to a carrier particle with an average diameter of from 0.1 microns to 15 microns, are used in topical treatment of bacterial infection. Bacteriophage covalently attached to a carrier particle of average diameter 7 microns or less are used in systemic treatment of bacterial infection. A plurality of bacteriophages lytic against different bacterial strains gives wide antibacterial activity. A combination therapy comprises administration of antibiotic and bacteriophage covalently attached to a carrier particle.

Methods are provided for producing fat-soluble vitamin particles. The particles exhibit extended shelf life and cooking stability and can be made without mineral acids or organic solvents. The particles are composite particles of a pH sensitive polymer and a fat-soluble vitamin such as vitamin A. The particles can be incorporated into foodstuffs such as bouillon, cereals, wheat flour, millet flour, cassava flour, tapioca flour, teff flour, corn meal, milk, milk powder, malt beverages, soy sauce, ready-to-use therapeutic foods, rice, or sugar. The foods can provide stable sources of vitamin A for populations in need thereof.