A composition comprising silica shells conjugated to a TLR7 agonist and methods of using the composition are provided.

The present invention relates to a polyplex composition for modulating expression of a gene-of-interest in an insect comprising: a crosslinker, a cation, and a molecule for initiating RNA interference (RNAi). The present invention further relates to polyplex compositions for modulating genes of interest in Aedes aegypti. The present invention further relates to methods of modulating a gene-of-interest in an insect, comprising: administering to an insect a polyplex composition for modulating expression of a gene-of-interest in an insect comprising: a crosslinker, a cation, and a molecule for initiating RNA interference (RNAi).

A method of treatment is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug by at least one of intravenously, systemically, intravitreally, through the choroid, in the cerebrospinal fluid (CSF), topically, through the conjunctival mucosa, through the nasal mucosa, through the cornea, through the retinal optic nerve, through the nasal mucosa olfactory nerve, in the brain, in the spinal cord, the biocompatible drug comprising one or more cell pathway inhibitors together with one or more complement pathway inhibitors and/or one or more TGF beta inhibitors, the patient having one or more neurodegenerative disorders. The administration of the biocompatible drug to the patient treats the one or more neurodegenerative disorders, reduces the symptoms associated with the one or more neurodegenerative disorders, and/or alleviates the one or more neurodegenerative disorders.

Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.

Provided herein are methods of treatment, compositions, systems and kits using polymer particles as restraints of neutrophil function. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which neutrophils may be implicated. In some embodiments, polymer particles are useful for diagnosing neutrophil related diseases or conditions.

Disclosed herein are platelet-like particles incorporating antimicrobial metallic nanoparticles. The platelet-like particles include an ultra-low crosslinked polymeric microgel and fibrin targeting moiety. The antimicrobial metallic nanoparticles can be covalently or noncovalently incorporated into the platelet-like particles. The particles are useful to stop bleeding and to promote wound healing while at the same time suppressing bacterial infections that can accompany tissue damage.

The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.

Described are polymers and methods of forming and using same.

The present invention relates to a porous microsphere comprising a mussel adhesive protein and a method of preparing the same. The porous microsphere comprising the mussel adhesive protein according to the present invention is capable of minimally invasive bio-injection through syringes to efficiently deliver therapeutic stem cells to the sites of tissue defects as cell carriers. Further, the present invention may be widely applied to scaffolds for tissue engineering, drug carriers, or the like, which may be suitably applied to the size of the defected site of tissue.

Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.