In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.

In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.

The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

Provided herein is injectable and/or sprayable, in situ polymerizable collagen-based compositions for sustained delivery of therapeutics (active agents, such as drugs, proteins, and other therapeutic agents). The compositions comprise (i) a neutral collagen solution, which is injectable or sprayable and capable of converting into a fibrous collagen mass or gel upon contacting with a physiological fluid or solution, or water; and (ii) a biologically or pharmaceutically active agent in the neutral collagen solution. The compositions are in the form of clear, transparent viscous solutions that instantaneously undergo gelation and polymerization when contacted by physiological fluids or solutions or water. The collagen solutions can be manipulated to provide various rates of sustained delivery of therapeutics.

The present invention relates to a viscoelastic composition for use in an ophthalmic surgery method, which is transparent and at the same time colored, which allow the surgeon to easily identify the composition during the ophthalmic surgery which facilitates viscoelastic removal at the end of the operation. The present invention also concerns an ophthalmic viscoelastic device which includes the viscoelastic composition of the present invention, and a method of performing an ophthalmic surgery on the eye of a subject, having a step of administering to said eye an effective amount of the viscoelastic composition.