The embodiments of the present invention disclose a conjugate compound of formula X-J-MAA, wherein X is a diagnostic or therapeutic radioisotope; J is an optional chelating agent; and MAA is macroaggregated albumin particles. The invention also discloses sterile and stable ready to use or reconstituted radiopharmaceutical composition of X-J-MAA and manufacturing process thereof, preferably the invention relates to radiopharmaceutical compositions of .sup.99mTc. The prepared radiopharmaceutical compositions exhibit desirable technical attributes like stability, radiochemical purity, less impurities, pH, better bio-distribution and desirable average particle size for further administration to patients for therapeutic and diagnostic use.

Compositions, methods, and uses of an alpha emitter are provided in which the alpha emitter is coupled to carrier protein via a cleavable coupling moiety. The coupling moiety is preferably cleavable in an acidic tumor microenvironment, and as such will enrich the alpha emitter upon cleavage within the tumor microenvironment.

The present invention provides a conjugate compound comprising a nanoparticulated enhanced permeability and retention (EPR) agent, which is an albumin, conjugated with one or more chelating agents, one or more target specific ligands and one or more detectable agents and optionally comprising one or more heterobifunctional crosslinkers and one or more pharmaceutically acceptable therapeutic agents. Further, the present invention provides a radiopharmaceutical composition and a kit comprising the said conjugate and also provides application of the same in diagnosis and therapy of various disease like cancer.

A phytic acid (PA)-based ternary complex biomimetic nanomaterial consisting of PA, metal ions and a protein/polypeptide is provided, and it is formed by connecting the protein/polypeptide with PA using metal cations as a cation bridge. The PA ternary complex having different protein/polypeptide groups is synthesized with various metal ions as bridges. A novel nanotheranostic probe having high biocompatibility is constructed. The probe may be reassembled and gathered persistently at tumor sites, allowing for the coordination loading of imaging/therapeutic metal ions. This enables long-lasting tumor imaging, treatment or integrated diagnosis and treatment, showing promise as a novel biomimetic nanomaterial in the field of biomedicine. In addition, the preparation process of the nanomaterial is simple and easy for industrial production.