Light disinfecting systems are provided in which light emanating from an end or side of optical fibers is used to disinfect a target site. According to one implementation a light beam emanating from an end emitting optical fiber is directed into a body that includes a plurality of optical surfaces that are configured to direct at least a portion of the end emitted beam of bacterial disinfecting light to the target site. The assembly may further include a substrate coupled to the body, the substrate including one or more channels in which reside one or more radially emitting optical fibers that are configured to radially emit bacterial disinfecting light towards the target site, the substrate being at least partially transparent to the bacterial disinfecting light.

A photoelectric device is disclosed. The photoelectric device includes a first electrode, a second electrode, and an electrolyte disposed between the first electrode and the second electrode. The second electrode includes a transparent layer for allowing light to penetrate into the second electrode, an electron transport layer coupled to the transparent layer, and a genetically hybridized fluorescent silk layer as a photo-sensitizer coupled to the electron transport layer.

Systems, devices and methods for controlled intramedullary delivery of light (frequencies from about 380 nm to about 500 nm) to treat tissue or bones disorders, including osteomyelitis, by a flexible fiber are provided, where the light is delivered in a circumferential fashion around the fiber, and where the energy delivered from the fiber is of a similar average intensity at the front end and back end of the fiber, and in between. The methods and systems deliver intramedullary light to the canal over long lengths via a minimally invasive pathway to a bone. The methods and systems deliver and maintain a light delivery system within the canal of the bone to provide single or multiple doses of light to kill, eliminate, remove or reduce bacteria, viruses, fungus and pathogens, without removal of the light fiber system, thereby providing single or multiple treatments.

A method of disinfection of a surface of a subject of harmful microorganisms including pathogenic bacteria and viruses upon visible light irradiation using a hybridized fluorescent silk is provided. The method includes placing a predetermined quantity of the hybridized fluorescent silk i) directly on to a skin surface of a subject; or ii) on a medium and then placing the medium on the skin surface of the subject. The method further includes applying light in the visible spectrum for a predetermined amount of time to the placed quantity of hybridized fluorescent silk, wherein the hybridized fluorescent silk is one of KillerRed, SuperNova, KillerOrange, Dronpa, TurboGFP, mCherry, or any combination thereof.

Disclosed herein are methods and devices for the inactivation of pathogens (e.g., bacteria, viruses, etc.) in ex vivo stored blood products, such as plasma and/or platelets, by means of directing visible light radiation from an illuminating device into blood product storage containers in order to achieve effective pathogen inactivation without the presence of an added photosensitising agent in the blood product. An exemplary apparatus includes a control unit that operates a light source that emits light in the wavelength region of about 380-500 nm which is directed onto blood product storage bags at sufficient intensity to penetrate the bag material and the opaque blood product therein in order to inactivate pathogens in the blood product but at dose levels that cause no significant detrimental effects on the blood product.

A lighting apparatus including a controller, an LED driver, and an LED luminaire including: a first light emitting unit for general lighting; and at least one of a second light emitting unit to cause production of vitamin D upon irradiation, a third light emitting unit to cause production of a cell activating substance upon irradiation, and a fourth light emitting unit to sterilize pathogenic microorganisms, in which the controller controls the LED driver to change a color temperature of the first light emitting unit in accordance with a change in a color temperature of sunlight, and to change an irradiance of light emitted from at least one of the second, third, and fourth light emitting units according to time, and the LED luminaire includes a greater number of the first light emitting unit than any of the second, third, and fourth light emitting units.

An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

An apparatus, system and computer program product for disinfecting a touch surface, comprising a structure having a touch surface and a heating element thermally coupled to the touch surface. A controller is coupled to the heating element, wherein the controller is configured to control heating power supplied to the heating element in a manner that heats the touch surface to a sufficient temperature for a sufficient period of time sufficient to sanitize the touch surface from viruses and microorganisms.

Selective extracorporeal blood disinfection systems and related methods are disclosed. The systems comprise an input tube forming a flowpath for the flow of infected blood. The systems further comprise a disinfection unit comprising a microbicidal light emitting device configured to emit visible light within the range of about 380-425 nm and/or about 500-700 nm, and a treatment flowpath in communication with the input tube that is substantially transparent to the emitted light of the microbicidal light emitting device for receiving at least a portion of the flow of the infected blood therethrough. The microbicidal light emitting device effectuates a dose of the emitted light to the infected blood flowing through the treatment flowpath to disinfect the blood. The systems also comprise an output tube in fluid communication with the treatment flowpath forming a flowpath for the flow of the disinfected blood from the disinfection unit.

Disclosed are compounds of general formula (I):

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and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.