Disclosed herein is a light emitting diode (LED) lighting device for sterilizing a surface or a space capable of effectively performing short-distance sterilization or long-distance sterilization. The device includes: a body including an inner transparent tube and an outer transparent tube in a double-tube type, the inner transparent tube forming a vertical ventilation hole and the outer transparent tube being spaced apart from the inner transparent tube at a predetermined distance; a substrate provided in a space formed by the inner transparent tube and the outer transparent tube; and a first light emitting element and a second light emitting element provided on an outer surface of the substrate. The first light emitting element emits visible light having a first wavelength of 405 nm, and the second light emitting element emits short-wavelength visible light having a second wavelength in the range of 400 to 450 nm.

Portable multifunctional device designed for sanitizing of inner and outer surfaces of shoes, sanitizing of air, water, household items and surfaces, treatment of skin and wound infection, nails fungus, cosmetic use, and detection of counterfeit currency. The device is able to perform all the above sanitizing, therapeutic and cosmetic functions that would otherwise be carried out by various different devices. The enhance functionality has been accomplished without alteration of any parts of the device. Apparatus utilizes light radiation in three diapasons: 100-280, 405-495, and 700-1064 nm and provides distant sanitizing. Apparatus comprises at least one module with a dual DC-AC power supply. Each module has a germicidal unit, retractable flexible shaft, shade, and housing. The flexible shaft allows positioning the germicidal units under different angle for uniform distant illumination. The device is suitable for household, traveling, and military use.

Methods and apparatus provide therapeutic electromagnetic radiation (EMR) for inactivating infectious agents in, on or around a catheter residing in a patient's body cavity and/or for enhancing healthy cell growth. The method comprises transmitting non-ultraviolet therapeutic EMR substantially axially along an optical element in a lumen of the catheter body and/or the catheter body. Through delivery of the therapeutic EMR to particular infected areas and/or areas requiring tissue healing. The methods and apparatus of the present disclosure inactivate the major sources of infection in, on, and around catheters and/or enhance healthy cell growth around catheters.

Disclosed herein is a blue light phototherapy system and methods of using the system to prevent and treat driveline bacterial infections, and particularly ventricular assist device driveline bacterial infections (Right Ventricular Assist Devices (RVAD) and Left Ventricular Assist Devices (LVAD)). The blue light phototherapy systems provide for both repeated and/or periodic antimicrobial treatment of soft tissue surrounding a driveline exit site on an individual. In many embodiments, the system includes one or more arrays of light emitting diodes (LED) of predominantly blue wavelengths in combination with a single or multi-piece biocompatible structure that captures the arrays and provides for a fixed distance from the arrays to the exit site tissue surface.

Systems and methods for multiple band visible light disinfection are disclosed. In some examples, a disinfecting light is generated by combining two different disinfecting wavelength ranges of light. A lighting device may comprise a first light source that generates light in a Soret band. The lighting device may further comprise a second light source that generates light in a Q band. The light in the Soret band and the light in the Q band may be combined to generate disinfecting light.

A therapeutic endotracheal tube assembly is provided for insertion into a patient's trachea to ventilate, to maintain patency of the patient's airway, and to deliver therapeutic electromagnetic radiation (EMR) to the patient. The therapeutic endotracheal tube assembly has an endotracheal tube and an EMR delivery system. The EMR delivery system has an EMR source for emitting non-ultraviolet, therapeutic EMR having intensity sufficient to activate desired therapeutic properties within the patient and an EMR conduction line conducive to the propagation of EMR from the EMR source along the endotracheal tube. The EMR conduction line is removably insertable into the endotracheal tube. The therapeutic endotracheal tube assembly may be custom made or may be constructed by retrofitting a removably insertable EMR delivery system to an existing endotracheal tube.

A light source for emitting emitted light having an SPD comprising: (a) a plurality of light emitters including at least one violet solid-state emitter; (b) at least one phosphor; wherein said light emitters and said at least one phosphor being configured such that: at least 25% of the power within the SPD is in the range 390-420 nm, and the emitted light has a chromaticity which is within a Duv distance of less than 5 points from the Planckian locus.

Disclosed are compounds of general formula (I): ##STR00001##
and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

A medical device and method configured to disinfect a skin surface, the device comprising a power source that provides electric power, a light emitting source that uses electric power received from the power source to disinfect the skin surface, and a switch that is configured to be operated by user action, wherein upon activation of the switch, the electric power from the power source is received by the light emitting source to emit visible light and disinfect the skin surface.